ArticleCancers2011
Tumor cell seeding during surgery-possible contribution to metastasis formations.
Article in Cancers, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Recurrent basosquamous carcinoma of the forearm, a case report.JPRAS open · 2026Article
- Elevated intravesical pressure promotes circulating tumor cell release in an orthotopic mouse model of bladder cancer.In vitro cellular & developmental biology. Animal · 2026Article
- Primary peritoneal embryonal rhabdomyosarcoma in a 6-year-old girl with rapid post-surgical peritoneal recurrence possibly due to surgical tumor seeding: a case report and review of the literature.Journal of medical case reports · 2026Review
- Improvement of the sensitivity of circulating tumor DNA-based liquid biopsy: current approaches and future perspectives.Exploration of targeted anti-tumor therapy · 2025Review
- Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus.Frontiers in cell and developmental biology · 2023Article
- Estimating latent, dynamic processes of breast cancer tumour growth and distant metastatic spread from mammography screening data.Statistical methods in medical research · 2022Observational
- The Incidence of Breast Cancer Recurrence 10-32 Years After Primary Diagnosis.Journal of the National Cancer Institute · 2022Article
- Circulating ensembles of tumor-associated cells: A redoubtable new systemic hallmark of cancer.International journal of cancer · 2020Observational
- Rare Treatment for a Rare Tumor: Cryoablation of a Granular Cell Tumor.Gastrointestinal tumors · 2020Article
- Effect of Surgery or Radiotherapy of the Breast on Survival in Metastatic Disease: a Retrospective Cohort Study.Indian journal of surgical oncology · 2019Article
- Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects.Nature reviews. Clinical oncology · 2016Review
- The number of tumorspheres cultured from peripheral blood is a predictor for presence of metastasis in patients with breast cancer.Oncotarget · 2016Article
- In Vivo Long-Term Monitoring of Circulating Tumor Cells Fluctuation during Medical Interventions.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spite of optimal local control in breast cancer, distant metastases can develop as a systemic part of this disease. Surgery is suspected to contribute to metastasis formation activating dormant tumor cells. Here we add data that seeding of cells during surgery may add to the risk of metastasis formation. The change in circulating epithelial tumor cells (CETC) was monitored in 66 breast cancer patients operated on with breast conserving surgery or mastectomy and during the further course of the disease, analyzing CETC from unseparated white blood cells stained with FITC-anti-EpCAM. An increase in cell numbers lasting until the start of chemotherapy was observed in about one third of patients. It was more preeminent in patients with low numbers of CETC before surgery and, surprisingly, in patients without involved lymph nodes. Patients with the previously reported behavior-Reincrease in cell numbers during adjuvant chemotherapy and subsequent further increase during maintenance therapy-were at increased risk of relapse. In addition to tumor cells already released during growth of the tumor, cell seeding during surgery may contribute to the early peak of relapses observed after removal of the primary tumor and chemotherapy may only marginally postpone relapse in patients with aggressively growing tumors.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.