ArticleCancers2011
Assessment of Serosal Invasion and Criteria for the Classification of Pathological (p) T4 Staging in Colorectal Carcinoma: Confusions, Controversies and Criticisms.
Article in Cancers, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- The clinical significance of elastic lamina invasion in patients with pStage II colorectal cancer: a notable prognostic indicator.World journal of surgical oncology · 2024Article
- Prognostic value of elastic lamina staining in patients with stage III colon cancer.World journal of surgical oncology · 2022Article
- Article
- Preoperative T staging of advanced colorectal cancer by computed tomography colonography.International journal of colorectal disease · 2021Article
- T3 versus T4a staging challenges in deeply invasive colonic adenocarcinomas and correlation with clinical outcomes.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Development of a Risk Score and Nomogram to Predict Individual Benefit Attained from the Addition of Adjuvant Chemotherapy in the Treatment of Stage II Colon Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Interobserver, intraobserver, and interlaboratory variability in reporting pT4a colon cancer.Virchows Archiv : an international journal of pathology · 2020Article
- Challenges with colorectal cancer staging: results of an international study.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- The prognostic significance of macroscopic serosal change in subserosal invasion (stage T3) gastric cancer.Annals of the Royal College of Surgeons of England · 2019Article
- Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade).International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2019Article
- Correlation Between Clinical and Pathologic Staging in Colon Cancer: Implications for Neoadjuvant Treatment.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- The prognosis significance and application value of peritoneal elastic lamina invasion in colon cancer.PloS one · 2018Article
- Livin serves as a prognostic marker for mid-distal rectal cancer and a target of mid-distal rectal cancer treatment.Oncology letters · 2017Article
- Article
- Proactive Management for Gastric, Colorectal and Appendiceal Malignancies: Preventing Peritoneal Metastases with Hyperthermic Intraperitoneal Chemotherapy (HIPEC).Indian journal of surgical oncology · 2016Review
- Role of peritoneal lavage cytology and prediction of prognosis and peritoneal recurrence after curative surgery for colorectal cancer.Annals of coloproctology · 2014Article
- Controversies in the pathological assessment of colorectal cancer.World journal of gastroenterology · 2014Review
- Prognostic biomarkers in colorectal cancer: where do we stand?Virchows Archiv : an international journal of pathology · 2014Review
- Elastic laminal invasion in colon cancer: diagnostic utility and histological features.Frontiers in oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmural spread by colorectal carcinoma can result in tumor invasion of the serosal surface and, hence, more likely dissemination within the peritoneal cavity and potentially to additional metastatic sites. The adverse prognostic significance of serosal invasion is widely accepted and its presence may be considered an indication for chemotherapy in patients with node negative disease. However, controversy persists regarding the most appropriate criteria for diagnosis and there are also practical difficulties associated with histological assessment in some cases. Therefore, serosal invasion may be under-diagnosed in a significant proportion of tumors, potentially leading to sub-optimal treatment of high-risk patients. The examination of multiple microscopic sections combined with ancillary studies such as cytology preparations, elastin stains, and immunohistochemistry may prove beneficial in selected problematic cases, but these are not used routinely. The relative prognostic significance of serosal invasion and of direct tumor spread to other organs, both of which are incorporated within the pT4 category of the AJCC/UICC TNM staging system, remains unclear. Further studies are required to demonstrate whether recent adjustments to the TNM staging of pT4 tumors are appropriate.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.