ArticleApplied and environmental microbiology2014
Nanoscale cell wall deformation impacts long-range bacterial adhesion forces on surfaces.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Differential susceptibility of Streptococcus dentisani to dental surfaces: An atomic force microscopy study.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Single-cell analysis of lipopolysaccharide-mediated heterogeneity in Escherichia coli adhesion and mechanics.Archives of microbiology · 2025Article
- Organic particle scavenging by marine bacteria: influences of bacterial nanoscale surface properties.Applied and environmental microbiology · 2025Article
- Investigating Simulated Cellular Interactions on Nanostructured Surfaces with Antibacterial Properties: Insights from Force Curve Simulations.Nanomaterials (Basel, Switzerland) · 2025Article
- Hypertonic stress induced changes of Pseudomonas fluorescens adhesion towards soil minerals studied by AFM.Scientific reports · 2023Article
- Adhesion Forces of Oral Bacteria to Titanium and the Correlation with Biophysical Cellular Characteristics.Bioengineering (Basel, Switzerland) · 2022Article
- Eco-friendly bacteria-killing by nanorods through mechano-puncture with top selectivity.Bioactive materials · 2022Article
- Strategies to prevent, curb and eliminate biofilm formation based on the characteristics of various periods in one biofilm life cycle.Frontiers in cellular and infection microbiology · 2022Review
- Serotype-dependent adhesion of Shiga toxin-producingFrontiers in microbiology · 2022Article
- Mechano-bactericidal actions of nanostructured surfaces.Nature reviews. Microbiology · 2021Review
- Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications.Clinical oral investigations · 2020Review
- The Bacterial Anti-Adhesive Activity of Double-Etched Titanium (DAE) as a Dental Implant Surface.International journal of molecular sciences · 2020Article
- Biomimetic Functional Surfaces towards Bactericidal Soft Contact Lenses.Micromachines · 2020Review
- Role of adhesion forces in mechanosensitive channel gating in Staphylococcus aureus adhering to surfaces.NPJ biofilms and microbiomes · 2020Article
- Biomaterial-based possibilities for managing peri-implantitis.Journal of periodontal research · 2020Review
- A Skeptic's Guide to Bacterial Mechanosensing.Journal of molecular biology · 2020Review
- How bacteria recognise and respond to surface contact.FEMS microbiology reviews · 2020Review
- Analysis of the physicochemical properties of antimicrobial compositions with zinc oxide nanoparticles.Science and technology of advanced materials · 2019Article
- Plant Secondary Metabolite-Derived Polymers: A Potential Approach to Develop Antimicrobial Films.Polymers · 2018Review
- A novel protocol to prepare cell probes for the quantification of microbial adhesion and biofilm initiation on structured bioinspired surfaces using AFM for single-cell force spectroscopy: Dedicated to Prof. em. Dr. Dr. H.C. Karl Schügerl on the occasion of his 90th birthday.Engineering in life sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesion of bacteria occurs on virtually all natural and synthetic surfaces and is crucial for their survival. Once they are adhering, bacteria start growing and form a biofilm, in which they are protected against environmental attacks. Bacterial adhesion to surfaces is mediated by a combination of different short- and long-range forces. Here we present a new atomic force microscopy (AFM)-based method to derive long-range bacterial adhesion forces from the dependence of bacterial adhesion forces on the loading force, as applied during the use of AFM. The long-range adhesion forces of wild-type Staphylococcus aureus parent strains (0.5 and 0.8 nN) amounted to only one-third of these forces measured for their more deformable isogenic Δpbp4 mutants that were deficient in peptidoglycan cross-linking. The measured long-range Lifshitz-Van der Waals adhesion forces matched those calculated from published Hamaker constants, provided that a 40% ellipsoidal deformation of the bacterial cell wall was assumed for the Δpbp4 mutants. Direct imaging of adhering staphylococci using the AFM peak force-quantitative nanomechanical property mapping imaging mode confirmed a height reduction due to deformation in the Δpbp4 mutants of 100 to 200 nm. Across naturally occurring bacterial strains, long-range forces do not vary to the extent observed here for the Δpbp4 mutants. Importantly, however, extrapolating from the results of this study, it can be concluded that long-range bacterial adhesion forces are determined not only by the composition and structure of the bacterial cell surface but also by a hitherto neglected, small deformation of the bacterial cell wall, facilitating an increase in contact area and, therewith, in adhesion force.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.