ArticleJournal of mathematical biology2014
A coupled mechano-biochemical model for bone adaptation.
Article in Journal of mathematical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 35 citations in OpenAlex.
- Statistical mechanics of soft collagenous tissues: a constitutive model with damage for cerebral bridging veins.European biophysics journal : EBJ · 2026Article
- On the effect of antiresorptive drugs on the bone remodeling of the mandible after dental implantation: a mathematical model.Scientific reports · 2021Article
- Toward a Mathematical Modeling of Diseases' Impact on Bone Remodeling: Technical Review.Frontiers in bioengineering and biotechnology · 2020Review
- Salvianolic acid B and danshensu induce osteogenic differentiation of rat bone marrow stromal stem cells by upregulating the nitric oxide pathway.Experimental and therapeutic medicine · 2017Article
- On the Use of Bone Remodelling Models to Estimate the Density Distribution of Bones. Uniqueness of the Solution.PloS one · 2016Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone remodelling is a fundamental biological process that controls bone microrepair, adaptation to environmental loads and calcium regulation among other important processes. It is not surprising that bone remodelling has been subject of intensive both experimental and theoretical research. In particular, many mathematical models have been developed in the last decades focusing in particular aspects of this complicated phenomenon where mechanics, biochemistry and cell processes strongly interact. In this paper, we present a new model that combines most of these essential aspects in bone remodelling with especial focus on the effect of the mechanical environment into the biochemical control of bone adaptation mainly associated to the well known RANKL-RANK-OPG pathway. The predicted results show a good correspondence with experimental and clinical findings. For example, our results indicate that trabecular bone is more severely affected both in disuse and disease than cortical bone what has been observed in osteoporotic bones. In future, the methodology proposed would help to new therapeutic strategies following the evolution of bone tissue distribution in osteoporotic patients.
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