Evidence map›Paper›PMID 24212393›Full record

Trial reportNeurology2013

An RCT to treat learning impairment in multiple sclerosis: The MEMREHAB trial.

Nancy D Chiaravalloti, Nancy B Moore, Olga M Nikelshpur, John DeLuca

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 165 citations in OpenAlex.

  1. Memory rehabilitation for people with multiple sclerosis.The Cochrane database of systematic reviews · 2021
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  5. Motor, cognitive, and combined rehabilitation approaches on MS patients' cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nancy D ChiaravallotiFrom the Kessler Foundation Neuropsychology and Neuroscience Laboratory (N.D.C., N.B.M., O.M.N., J.D.), West Orange; and Departments of Physical Medicine and Rehabilitation (N.D.C., O.M.N., J.D.) and Neurology & Neurosciences (J.D.), Rutgers, New Jersey Medical School, Newark, NJ.
Nancy B Moore
Olga M Nikelshpur
John DeLuca
Kessler Foundation · US

Funding

Improving Learning in MS: A Randomized Clinical TrialR01HD045798 · NICHD · KESSLER MEDICAL REHAB RES &EDUC CORP · PI CHIARAVALLOTI, NANCY D. · 2004 to 2008
$2.1M
NICHD NIH HHS R01 HD045798
6 · The paper itself

Abstract

objectiveTo examine the efficacy of the modified Story Memory Technique (mSMT), a 10-session behavioral intervention teaching context and imagery to facilitate learning, to improve learning and memory abilities in persons with multiple sclerosis (MS).

methodsThis double-blind, placebo-controlled, randomized clinical trial included 86 participants with clinically definite MS, 41 in the treatment group and 45 in the placebo control group. Participants completed a baseline neuropsychological assessment, including questionnaires assessing everyday memory, a repeat assessment immediately posttreatment, and a long-term follow-up assessment 6 months after treatment. After completion of the treatment phase, persons in the treatment group were assigned to a booster session or a non-booster session group to examine the efficacy of monthly booster sessions in facilitating the treatment effect over time.

resultsThe treatment group showed a significantly improved learning slope relative to the placebo group posttreatment. Similar results were noted on objective measures of everyday memory, general contentment, and family report of apathy and executive dysfunction. Long-term follow-up data showed that posttreatment improvement in the treatment group continued to be noted on the list learning and self-report measures. The provision of booster sessions demonstrated little benefit.

conclusionThe mSMT is effective for improving learning and memory in MS. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that the mSMT behavioral intervention improves both objective memory and everyday memory in patients with MS over 5 weeks, with treatment effects lasting over a 6-month period.

Indexed as

Neuropsychological TestsAdultDouble-Blind MethodFemaleFollow-Up StudiesHumansLearningMaleMemory DisordersMiddle AgedMultiple SclerosisTime FactorsTreatment Outcome

Identifiers

PMID24212393
PMCPMC3863346
OpenAlexW2147832256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.