ArticleIndian journal of ophthalmology2013
Evaluation of changes in retinal nerve fiber layer thickness and visual functions in cases of optic neuritis and multiple sclerosis.
Article in Indian journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Consensus statement for the diagnosis and management of optic neuritis.Indian journal of ophthalmology · 2026Review
- Optical Coherence Tomography Angiography Findings in Primary Progressive Multiple Sclerosis Patients Receiving Ocrelizumab Treatment.Diagnostics (Basel, Switzerland) · 2026Article
- Evaluation of Accommodation Amplitude and Convergence Insufficiency in Patients with Multiple Sclerosis.Neuro-ophthalmology (Aeolus Press) · 2025Article
- Effects of sodium valproate and levetiracetam on posterior segment parameters in children with epilepsy.International ophthalmology · 2024Article
- Evaluation of ganglion cell complex and retinal nerve fiber layer thinning in epilepsy patients.Indian journal of ophthalmology · 2023Article
- Machine learning classification of multiple sclerosis in children using optical coherence tomography.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Neuroprotective Effects of Novel Treatments on Acute Optic Neuritis-A Meta-Analysis.Biomedicines · 2022Article
- Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman.BMC ophthalmology · 2021Article
- Approach to optic neuritis: An update.Indian journal of ophthalmology · 2021Review
- Visual function and inner retinal structure correlations in aquaporin-4 antibody-positive optic neuritis.Japanese journal of ophthalmology · 2018Article
- Retinal nerve fiber layer and ganglion cell layer changes on optical coherence tomography in early multiple sclerosis and optic neuritis cases.Indian journal of ophthalmology · 2018Article
- Evaluation of the Radiation Dose-Volume Effects of Optic Nerves and Chiasm by Psychophysical, Electrophysiologic Tests, and Optical Coherence Tomography in Nasopharyngeal Carcinoma.Technology in cancer research & treatment · 2017Article
- Multiple Sclerosis in India.Annals of Indian Academy of NeurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextRetinal nerve fiber layer (RNFL) thinning has been demonstrated in cases of optic neuritis (ON) and multiple sclerosis (MS) in Caucasian eyes, but no definite RNFL loss pattern or association with visual functions is known in Indian eyes.
aimTo evaluate RNFL thickness in cases of ON and MS, and to correlate it with visual function changes in Indian patients. SETTINGS AND
designCross-sectional case-control study at a tertiary level institution. MATERIALS AND
methodsCases consisted of patients of (i) typical ON without a recent episode (n = 30:39 ON eyes and 21 fellow eyes), (ii) MS without ON (n = 15;30 eyes) while the controls were age-matched (n = 15; 30 eyes). RNFL thickness was measured using the Stratus 3 °CT. The visual functions tested included the best-corrected visual acuity (BCVA), contrast sensitivity, stereopsis, visual evoked responses, and visual fields. STATISTICAL ANALYSIS USED: Intergroup analysis was done using ANOVA and Pearson's correlation coefficient used for associations.
resultsRNFL thickness was reduced significantly in the ON and MS patients compared to the controls (P-0.001). Maximum loss is in the temporal quadrant. Lower visual function scores are associated with reduced average overall RNFL thickness. In ON group, RNFL thinning is associated with severe visual field defects while contrast sensitivity has strongest correlation with RNFL in the MS group.
conclusionsRNFL thickness is reduced in ON and MS cases in a pattern similar to Caucasians and is associated with the magnitude of impairment of other visual parameters. Contrast sensitivity and stereoacuity are useful tests to identify subclinical optic nerve involvement in multiple sclerosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.