Evidence map›Paper›PMID 24212137›Full record

ArticleExperimental gerontology2014

Prospective associations between inflammatory and hemostatic markers and physical functioning limitations in mid-life women: Longitudinal results of the Study of Women's Health Across the Nation (SWAN).

Candace K McClure, Samar R El Khoudary, Carrie A Karvonen-Gutierrez, Kelly R Ylitalo, Kristin Tomey, Trang VoPham, Barbara Sternfeld, Jane A Cauley, Siobán Harlow

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental gerontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Physical Activity and Physical Function: Moving and Aging.Obstetrics and gynecology clinics of North America · 2018
    Review
  7. Article
  8. Observational
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Candace K McClureDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, USA. Electronic address: mcclurec@edc.pitt.edu.
Samar R El KhoudaryDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, USA.
Carrie A Karvonen-GutierrezDepartment of Epidemiology, University of Michigan School of Public Health, USA.
Kelly R YlitaloDepartment of Epidemiology, University of Michigan School of Public Health, USA.
Kristin TomeyDepartment of Epidemiology, University of Michigan School of Public Health, USA.
Trang VoPhamDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, USA.
Barbara SternfeldKaiser Permanente Division of Research, Oakland, CA, USA.
Jane A CauleyDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, USA.
Siobán HarlowDepartment of Epidemiology, University of Michigan School of Public Health, USA.

Funding

WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
Trajectories of Physical & Cognitive Functioning in the Neighborhood EnvironmentK01AG039554 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AUGUST, ELLA · 2011 to 2014
$478k
NIA NIH HHS K01 AG039554NIA NIH HHS U01 AG012495NIA NIH HHS U01AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01AG012553NIA NIH HHS U01 AG012554NIA NIH HHS U01AG012554NINR NIH HHS U01 NR004061NINR NIH HHS U01NR004061
6 · The paper itself

Abstract

backgroundDue to the public health burden of age-related declines in physical functioning, it is important to identify targets for intervention for the prevention of functional decline. We prospectively examined whether higher levels of inflammatory and hemostatic markers (high-sensitivity C-reactive protein (hs-CRP), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator antigen (tPA-ag), fibrinogen, and Factor VIIc (FVIIc)) were prospectively associated with reporting greater limitations in perceived physical functioning, and explored potential racial differences in the associations, in a multi-ethnic sample of mid-life women.

methodsWomen (45-56 years) in the Study of Women's Health Across the Nation who completed the physical functioning scale of the Medical Outcome Short Form (SF-36) at follow-up visits 4, 6, or 8 and had inflammatory/hemostatic measures in the preceding year were included (n=2296). The continuous SF-36 physical function score was categorized as: no limitation (86-100 points), some limitation (51-85 points), and substantial limitation (0-50 points). Physical function category at time t was modeled a function of each biomarker, separately, at time t-1 using ordinal generalized estimating equations.

resultsAfter adjusting for age, race/ethnicity, body size, sociodemographic, medical and lifestyle factors, higher levels of tPA-ag and hs-CRP were associated with subsequently reporting greater limitations in physical functioning, although the latter was only marginally significant (p=0.13). For each standard deviation (SD) increase in logtPA-ag, the odds of some or substantial limitations was 1.18 (95%CI 1.09,1.27); for each SD increase in loghs-CRP, the odds of some or substantial limitation was (1.08, 95%CI 0.98,1.19). In African American women only, higher fibrinogen levels were associated with subsequently reporting greater limitations (OR=1.30, 95%CI 1.13,1.50, for each one SD increase in fibrinogen).

conclusionsHigher levels of inflammatory and hemostatic markers were prospectively associated with greater limitations in perceived physical functioning in mid-life women.

Indexed as

Mobility LimitationBiomarkersBlood Coagulation FactorsC-Reactive ProteinFemaleHemostasisHumansInflammationInflammation MediatorsLongitudinal StudiesMenopauseMiddle AgedMotor ActivityProspective StudiesSocioeconomic FactorsTissue Plasminogen ActivatorBiomarkersBlood Coagulation FactorsC-Reactive ProteinInflammation MediatorsTissue Plasminogen ActivatorHemostasisInflammationMenopausal transitionPhysical functioningWomen

Identifiers

PMID24212137
PMCPMC3878447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.