ArticleJournal of theoretical biology2014
The effects of cell compressibility, motility and contact inhibition on the growth of tumor cell clusters using the Cellular Potts Model.
Article in Journal of theoretical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 64 citations in OpenAlex.
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- Numerical modeling of oxygen diffusion in tissue spheroids undergoing fusion using function representation and finite volumes.Scientific reports · 2025Article
- Improving 3D deep learning segmentation with biophysically motivated cell synthesis.Communications biology · 2025Article
- A seven-step guide to spatial, agent-based modelling of tumour evolution.Evolutionary applications · 2024Review
- Mechanical control of cell proliferation patterns in growing epithelial monolayers.Biophysical journal · 2024Article
- Bidirectionally validatedFrontiers in bioengineering and biotechnology · 2024Article
- Mechanical control of cell proliferation patterns in growing tissues.bioRxiv : the preprint server for biology · 2023Article
- Data-driven spatio-temporal modelling of glioblastoma.Royal Society open science · 2023Review
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- Impact of Force Function Formulations on the Numerical Simulation of Centre-Based Models.Bulletin of mathematical biology · 2020Article
- Unification of aggregate growth models by emergence from cellular and intracellular mechanisms.Royal Society open science · 2020Article
- Control of cell colony growth by contact inhibition.Scientific reports · 2020Article
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- The Wiring of Intelligence.Perspectives on psychological science : a journal of the Association for Psychological Science · 2019Article
- Review
- Microstencil-based spatial immobilization of individual cells for single cell analysis.Biomicrofluidics · 2018Article
- Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition.Scientific reports · 2017Article
- Spatio-temporal morphology changes in and quenching effects on the 2D spreading dynamics of cell colonies in both plain and methylcellulose-containing culture media.Journal of biological physics · 2016Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
There are numerous biological examples where genes associated with migratory ability of cells also confer the cells with an increased fitness even though these genes may not have any known effect on the cell mitosis rates. Here, we provide insight into these observations by analyzing the effects of cell migration, compression, and contact inhibition on the growth of tumor cell clusters using the Cellular Potts Model (CPM) in a monolayer geometry. This is a follow-up of a previous study (Thalhauser et al. 2010) in which a Moran-type model was used to study the interaction of cell proliferation, migratory potential and death on the emergence of invasive phenotypes. Here, we extend the study to include the effects of cell size and shape. In particular, we investigate the interplay between cell motility and compressibility within the CPM and find that the CPM predicts that increased cell motility leads to smaller cells. This is an artifact in the CPM. An analysis of the CPM reveals an explicit inverse-relationship between the cell stiffness and motility parameters. We use this relationship to compensate for motility-induced changes in cell size in the CPM so that in the corrected CPM, cell size is independent of the cell motility. We find that subject to comparable levels of compression, clusters of motile cells grow faster than clusters of less motile cells, in qualitative agreement with biological observations and our previous study. Increasing compression tends to reduce growth rates. Contact inhibition penalizes clumped cells by halting their growth and gives motile cells an even greater advantage. Finally, our model predicts cell size distributions that are consistent with those observed in clusters of neuroblastoma cells cultured in low and high density conditions.
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