ArticleEnvironmental toxicology and pharmacology2013
A pilot study: the importance of inter-individual differences in inorganic arsenic metabolism for birth weight outcome.
Article in Environmental toxicology and pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Unraveling the genetics of arsenic toxicity with cellular morphology QTL.PLoS genetics · 2024Article
- Urinary arsenic species and birth outcomes in Tacna, Peru, 2019: a prospective cohort study.UCL open. Environment · 2024Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Cell morphology QTL reveal gene by environment interactions in a genetically diverse cell population.bioRxiv : the preprint server for biology · 2023Article
- Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico.International journal of environmental research and public health · 2022Article
- Cord blood DNA methylation of DNMT3A mediates the association between in utero arsenic exposure and birth outcomes: Results from a prospective birth cohort in Bangladesh.Environmental research · 2020Article
- Determinants of arsenic methylation efficiency and urinary arsenic level in pregnant women in Bangladesh.Environmental health : a global access science source · 2019Article
- Gene-environment interaction and maternal arsenic methylation efficiency during pregnancy.Environment international · 2019Article
- Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic.Current environmental health reports · 2018Review
- Investigating causal relation between prenatal arsenic exposure and birthweight: Are smaller infants more susceptible?Environment international · 2017Article
- A Review of the Effects of Chronic Arsenic Exposure on Adverse Pregnancy Outcomes.International journal of environmental research and public health · 2017Review
- Developmental Windows of Susceptibility to Inorganic Arsenic: A Survey of Current Toxicologic and Epidemiologic Data.Toxicology research · 2016Article
- Epigenome-Wide Assessment of DNA Methylation in the Placenta and Arsenic Exposure in the New Hampshire Birth Cohort Study (USA).Environmental health perspectives · 2016Article
- Low level arsenic contaminated water consumption and birth outcomes in Romania-An exploratory study.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- Maternal arsenic exposure and birth outcomes: a comprehensive review of the epidemiologic literature focused on drinking water.International journal of hygiene and environmental health · 2014Review
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
Inorganic arsenic (iAs) exposure is detrimental to birth outcome. We lack information regarding the potential for iAs metabolism to affect fetal growth. Our pilot study evaluated postpartum Romanian women with known birth weight outcome for differences in iAs metabolism. Subjects were chronically exposed to low-to-moderate drinking water iAs. We analyzed well water, arsenic metabolites in urine, and toenail arsenic. Urine iAs and metabolites, toenail iAs, and secondary methylation efficiency increased as an effect of exposure (p<0.001). Urine iAs and metabolites showed a significant interaction effect between exposure and birth weight. Moderately exposed women with low compared to normal birth weight outcome had greater metabolite excretion (p<0.03); 67% with low compared to 10% with normal birth weight outcome presented urine iAs >9 μg/L (p=0.019). Metabolic partitioning of iAs toward excretion may impair fetal growth. Prospective studies on iAs excretion before and during pregnancy may provide a biomarker for poor fetal growth risk.
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