ArticleBiosensors & bioelectronics2014
Nanopore detection of copper ions using a polyhistidine probe.
Article in Biosensors & bioelectronics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Electrode Modality Development in Pulsed Electric Field Treatment Facilitates Biocellular Mechanism Study and Improves Cancer Ablation Efficacy.Journal of healthcare engineering · 2017Pooled it
- Nanopore Environmental Analysis.JACS Au · 2025Review
- Nanopore Detection of Small Molecules Based on Replacement and Complexation Chemical Interactions.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Redesign of Translocon EXP2 Nanopore for Detecting Peptide Fragments.Small methods · 2025Article
- Probe-assisted detection of FeBiosensors & bioelectronics · 2024Article
- Recent Advances in Nanopore Technology for Copper Detection and Their Potential Applications.Nanomaterials (Basel, Switzerland) · 2023Review
- Nanopore Single-molecule Analysis of Biomarkers: Providing Possible Clues to Disease Diagnosis.Trends in analytical chemistry : TRAC · 2023Article
- Novel Fluorescence Probe toward CuBiosensors · 2022Article
- A Highly Sensitive and Selective Fluorescein-Based CuFrontiers in nutrition · 2022Article
- Nanopore detection of metal ions: Current status and future directions.Small methods · 2020Article
- Ultrasensitive and Selective Copper(II) Detection: Introducing a Bioinspired and Robust Sensor.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- DNA nanotechnology assisted nanopore-based analysis.Nucleic acids research · 2020Review
- Computation-Assisted Nanopore Detection of Thorium Ions.Analytical chemistry · 2018Article
- Label-Free Detection of DNA Mutations by Nanopore Analysis.ACS applied materials & interfaces · 2018Article
- Peptide-Mediated Nanopore Detection of Uranyl Ions in Aqueous Media.ACS sensors · 2017Article
- A Protein Nanopore-Based Approach for Bacteria Sensing.Nanoscale research letters · 2016Article
- Label-free nanopore single-molecule measurement of trypsin activity.ACS sensors · 2016Article
- Nanopore back titration analysis of dipicolinic acid.Electrophoresis · 2015Article
- Real-time label-free measurement of HIV-1 protease activity by nanopore analysis.Biosensors & bioelectronics · 2014Article
- Probing of various physiologically relevant metals-amyloid-β peptide interactions with a lipid membrane-immobilized protein nanopore [corrected].The Journal of membrane biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
We report a stochastic nanopore sensing method for the detection of Cu(2+) ions. By employing a polyhistidine molecule as a chelating agent, and based on the different signatures of the events produced by the translocation of the chelating agent through an α-hemolysin pore in the absence and presence of target analytes, trace amounts of copper ions could be detected with a detection limit of 40 nM. Importantly, although Co(2+), Ni(2+), and Zn(2+) also interacts with the polyhistidine molecule, since the event residence times and/or blockage amplitudes for these metal chelates are significantly different from those of copper chelates, these metal ions do not interfere with Cu(2+) detection. This chelating reaction approach should find useful application in the development of nanopore sensors for other metal ions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.