ArticleBehavioural brain research2014
Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons.
Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- An alpha 5-GABAAutism research : official journal of the International Society for Autism Research · 2024Article
- Component-specific reduction in perineuronal nets in senescence-accelerated mouse strains.IBRO neuroscience reports · 2023Article
- Parvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention.Frontiers in integrative neuroscience · 2022Review
- Reversing frontal disinhibition rescues behavioural deficits in models of CACNA1A-associated neurodevelopment disorders.Molecular psychiatry · 2021Article
- Sensorimotor developmental factors influencing the performance of laboratory rodents on learning and memory.Behavioural brain research · 2019Review
- Medial prefrontal cortex in neurological diseases.Physiological genomics · 2019Review
- Maturational Changes in Prefrontal and Amygdala Circuits in Adolescence: Implications for Understanding Fear Inhibition during a Vulnerable Period of Development.Brain sciences · 2019Review
- Early Life Stress Drives Sex-Selective Impairment in Reversal Learning by Affecting Parvalbumin Interneurons in Orbitofrontal Cortex of Mice.Cell reports · 2018Article
- Common basis for orofacial clefting and cortical interneuronopathy.Translational psychiatry · 2018Article
- Touchscreen learning deficits and normal social approach behavior in the Shank3B model of Phelan-McDermid Syndrome and autism.Neuroscience · 2017Article
- Neurophysiology of rule switching in the corticostriatal circuit.Neuroscience · 2017Review
- Prefrontal cortical GABAergic signaling and impaired behavioral flexibility in aged F344 rats.Neuroscience · 2017Article
- Gene-environment interactions in cortical interneuron development and dysfunction: A review of preclinical studies.Neurotoxicology · 2017Review
- Multimodal and Site-Specific Plasticity of Amygdala Parvalbumin Interneurons after Fear Learning.Neuron · 2016Article
- Effects of acute administration of the GABA(B) receptor agonist baclofen on behavioral flexibility in rats.Psychopharmacology · 2016Article
- Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Insulin-Independent GABAA Receptor-Mediated Response in the Barrel Cortex of Mice with Impaired Met Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Merging data from genetic and epigenetic approaches to better understand autistic spectrum disorder.Epigenomics · 2016Article
- Rule encoding in dorsal striatum impacts action selection.The European journal of neuroscience · 2015Article
- Long-range GABAergic neurons in the prefrontal cortex modulate behavior.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Alterations of inhibitory GABAergic neurons are implicated in multiple psychiatric and neurological disorders, including schizophrenia, autism and epilepsy. In particular, interneuron deficits in prefrontal areas, along with presumed decreased inhibition, have been reported in several human patients. The majority of forebrain GABAergic interneurons arise from a single subcortical source before migrating to their final regional destination. Factors that govern the interneuron populations have been identified, demonstrating that a single gene mutation may globally affect forebrain structures or a single area. In particular, mice lacking the urokinase plasminogen activator receptor (Plaur) gene have decreased GABAergic interneurons in frontal and parietal, but not caudal, cortical regions. Plaur assists in the activation of hepatocyte growth factor/scatter factor (HGF/SF), and several of the interneuron deficits are correlated with decreased levels of HGF/SF. In some cortical regions, the interneuron deficit can be remediated by endogenous overexpression of HGF/SF. In this study, we demonstrate decreased parvalbumin-expressing interneurons in the medial frontal cortex, but not in the hippocampus or basal lateral amygdala in the Plaur null mouse. The Plaur null mouse demonstrates impaired medial frontal cortical function in extinction of cued fear conditioning and the inability to form attentional sets. Endogenous HGF/SF overexpression increased the number of PV-expressing cells in medial frontal cortical areas to levels greater than found in wildtype mice, but did not remediate the behavioral deficits. These data suggest that proper medial frontal cortical function is dependent upon optimum levels of inhibition and that a deficit or excess of interneuron numbers impairs normal cognition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.