Evidence map›Paper›PMID 24211020›Full record

ArticleBioorganic & medicinal chemistry letters2013

Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.

William C Motel, Jason R Healy, Eddy Viard, Buddy Pouw, Kelly Martin, Rae R Matsumoto, Andrew Coop

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

William C Motel *Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 North Pine Street, Baltimore, MD, 21201, USA.
Jason R Healy *Department of Basic Pharmaceutical Sciences, West Virginia University, School of Pharmacy, One Medical Center Drive, Morgantown, WV, 26506, USA.
Eddy ViardDepartment of Basic Pharmaceutical Sciences, West Virginia University, School of Pharmacy, One Medical Center Drive, Morgantown, WV, 26506, USA.
Buddy PouwDepartment of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, College of Pharmacy, Oklahoma City, OK, 73190, USA.
Kelly MartinDepartment of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 North Pine Street, Baltimore, MD, 21201, USA.
Rae R MatsumotoDepartment of Basic Pharmaceutical Sciences, West Virginia University, School of Pharmacy, One Medical Center Drive, Morgantown, WV, 26506, USA.
Andrew CoopDepartment of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 North Pine Street, Baltimore, MD, 21201, USA.
University of Maryland, Baltimore · USWest Virginia University · USUniversity of Oklahoma Health Sciences Center · US

Funding

OPIOIDS WITH DELTA ANTAGONIST AND MU AGONIST ACTIVITYR01DA013583 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI COOP, ANDREW · 2001 to 2012
$2.5M
Synthesis &Evaluation of Cocaine AntagonistsR01DA013978 · NIDA · WEST VIRGINIA UNIVERSITY · PI MATSUMOTO, RAE R · 2001 to 2010
$1.9M
SIGMA LIGANDS FOR THE TREATMENT OF COCAINE OVERDOSER01DA011979 · NIDA · WEST VIRGINIA UNIVERSITY · PI MATSUMOTO, RAE R · 2000 to 2007
$1.3M
NIDA NIH HHS DA011979NIDA NIH HHS DA013583NIDA NIH HHS DA013978NIDA NIH HHS R01 DA011979NIDA NIH HHS R01 DA013583NIDA NIH HHS R01 DA013978
6 · The paper itself

Abstract

Selective σ2 ligands continue to be an active target for medications to attenuate the effects of psychostimulants. In the course of our studies to determine the optimal substituents in the σ2-selective phenyl piperazines analogues with reduced activity at other neurotransmitter systems, we discovered that 1-(3-chlorophenyl)-4-phenethylpiperazine actually had preferentially increased affinity for dopamine transporters (DAT), yielding a highly selective DAT ligand.

Indexed as

LigandsDopamine Plasma Membrane Transport ProteinsNorepinephrine Plasma Membrane Transport ProteinsPiperazinesProtein BindingReceptors, sigmaSerotonin Plasma Membrane Transport ProteinsStructure-Activity RelationshipDopamine Plasma Membrane Transport ProteinsLigandsNorepinephrine Plasma Membrane Transport ProteinsphenylpiperazinePiperazinesReceptors, sigmaSerotonin Plasma Membrane Transport ProteinsCocaineDopamine transporterMethamphetamineNeurotransmitterSigma receptorStructure–activity relationships

Identifiers

PMID24211020
PMCPMC3919026
OpenAlexW1969493960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.