ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2013
Cutaneous human papillomavirus types detected on the surface of male external genital lesions: a case series within the HPV Infection in Men Study.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Restriction of viral gene expression and replication prevents immortalization of human keratinocytes by a beta-human papillomavirus.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Cutaneous vs. Mucosal Tropism: The Papillomavirus Paradigm Comes to an "Frontiers in microbiology · 2020Article
- Prevalence and Correlates of β- and γ-Human Papillomavirus Detection in Oral Samples From Mid-Adult Women.The Journal of infectious diseases · 2019Article
- Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology.Frontiers in oncology · 2019Review
- Epidemiology and biology of cutaneous human papillomavirus.Clinics (Sao Paulo, Brazil) · 2018Review
- Generation of a novel next-generation sequencing-based method for the isolation of new human papillomavirus types.Virology · 2018Article
- Prevalence and correlates of beta human papillomavirus detection in fingernail samples from mid-adult women.Papillomavirus research (Amsterdam, Netherlands) · 2018Article
- Beta and gamma human papillomaviruses in anal and genital sites among men: prevalence and determinants.Scientific reports · 2018Article
- Cutaneous HPV and alpha-mucosal 9-valent HPV sero-status associations.Papillomavirus research (Amsterdam, Netherlands) · 2017Article
- Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Prevalence and Concordance of Cutaneous Beta Human Papillomavirus Infection at Mucosal and Cutaneous Sites.The Journal of infectious diseases · 2017Article
- Article
- Universal Human Papillomavirus Typing Assay: Whole-Genome Sequencing following Target Enrichment.Journal of clinical microbiology · 2017Article
- Seroprevalence of cutaneous human papillomaviruses (HPVs) among men in the multinational HPV Infection in Men study.The Journal of general virology · 2016Article
- Article
- Diversity of beta-papillomavirus at anogenital and oral anatomic sites of men: The HIM Study.Virology · 2016Article
- Seroprevalence of Cutaneous Human Papillomaviruses and the Risk of External Genital Lesions in Men: A Nested Case-Control Study.PloS one · 2016Article
- Role of histological findings and pathologic diagnosis for detection of human papillomavirus infection in men.Journal of medical virology · 2015Article
- Diversity of human papillomavirus in the anal canal of men: the HIM Study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2015Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundCutaneous human papillomaviruses (HPVs) may be associated with cutaneous epithelial lesions and non-melanoma skin cancers. No study has systematically evaluated the presence of genus beta [β]-HPV in male genital skin or external genital lesions (EGLs)
objectivesTo examine cutaneous β-HPV types detected on the surface of EGLs in men and describe their presence prior to EGL development. STUDY
designA retrospective case series was conducted among 69 men with pathologically confirmed EGLs (n=72) who participated in the HPV Infection in Men Study. Archived exfoliated cells collected from the surface of each EGL and normal genital skin specimens 6-12 months preceding EGL development were tested for β-HPV DNA using a type-specific multiplex genotyping assay.
resultsβ-HPV DNA was detected on 61.1% of all EGLs, with types 38 (16.7%), 5 (15.3%), and 12 (12.5%) most commonly identified. HPV prevalence differed across pathological diagnoses, with the largest number of β-HPV types detected on condylomas. Most β-HPV types were detected on normal genital skin prior to EGL development, though the prevalence was lower on EGLs compared to preceding normal genital skin.
conclusionsEGLs and the normal genital skin of men harbor a large number of β-HPV types; however, it appears that β-HPVs are unrelated to EGL development in men. Despite evidence to support a causal role in skin carcinogenesis at UVR-exposed sites, cutaneous HPV appears unlikely to cause disease at the UVR-unexposed genitals.
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