ArticlePsychiatry research2014
Basal ganglia volume in unmedicated patients with schizophrenia is associated with treatment response to antipsychotic medication.
Article in Psychiatry research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Brain Structural Effects of Antipsychotic Treatment in Schizophrenia: A Systematic Review.Current neuropharmacology · 2015Pooled it
- Increased regional homogeneity modulated by metacognitive training predicts therapeutic efficacy in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2021Trial
- Fiber architecture in the human ventromedial striatum and its relation with the bed nucleus of the stria terminalis.PloS one · 2025Article
- Decreased basal ganglia and thalamic iron in early psychotic spectrum disorders are associated with increased psychotic and schizotypal symptoms.Molecular psychiatry · 2022Article
- Increased subcortical region volume induced by electroconvulsive therapy in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2021Article
- Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia.Neural plasticity · 2021Observational
- Characteristics of Multimodal Brain Connectomics in Patients With Schizophrenia and the Unaffected First-Degree Relatives.Frontiers in cell and developmental biology · 2021Article
- Thalamus Radiomics-Based Disease Identification and Prediction of Early Treatment Response for Schizophrenia.Frontiers in neuroscience · 2021Article
- Neuroimaging as a Window Into the Pathophysiological Mechanisms of Schizophrenia.Frontiers in psychiatry · 2021Review
- Numerical density of oligodendrocytes and oligodendrocyte clusters in the anterior putamen in major psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2020Article
- Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State.Schizophrenia bulletin · 2020Article
- Brain findings associated with risperidone in rhesus monkeys: magnetic resonance imaging and pathology perspectives.Journal of toxicologic pathology · 2019Article
- Article
- Socioeconomic disadvantage, brain morphometry, and attentional bias to threat in middle childhood.Cognitive, affective & behavioral neuroscience · 2019Article
- Prediction of early response to overall treatment for schizophrenia: A functional magnetic resonance imaging study.Brain and behavior · 2019Article
- Examining resting-state functional connectivity in first-episode schizophrenia with 7T fMRI and MEG.NeuroImage. Clinical · 2019Article
- Four-way multimodal fusion of 7 T imaging data using an mCCA+jICA model in first-episode schizophrenia.Human brain mapping · 2018Article
- Gyrification Connectomes in Unmedicated Patients With Schizophrenia and Following a Short Course of Antipsychotic Drug Treatment.Frontiers in psychiatry · 2018Article
- Predicting individualized clinical measures by a generalized prediction framework and multimodal fusion of MRI data.NeuroImage · 2017Article
- Genome-wide association study of paliperidone efficacy.Pharmacogenetics and genomics · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the relationship between basal ganglia volume and treatment response to the atypical antipsychotic medication risperidone in unmedicated patients with schizophrenia. Basal ganglia volumes included the bilateral caudate, putamen, and pallidum and were measured using the Freesurfer automated segmentation pipeline in 23 subjects. Also, baseline symptom severity, duration of illness, age, gender, time off medication, and exposure to previous antipsychotic were measured. Treatment response was significantly correlated with all three regions of the bilateral basal ganglia (caudate, putamen, and pallidum), baseline symptom severity, duration of illness, and age but not gender, time off antipsychotic medication, or exposure to previous antipsychotic medication. The caudate volume was the basal ganglia region that demonstrated the strongest correlation with treatment response and was significantly negatively correlated with patient age. Caudate volume was not significantly correlated with any other measure. We demonstrated a novel finding that the caudate volume explains a significant amount of the variance in treatment response over the course of 6 weeks of risperidone pharmacotherapy even when controlling for baseline symptom severity and duration of illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.