Evidence map›Paper›PMID 24210923›Full record

Trial reportThe Journal of pediatrics2014

Variation in feeding practices following the Norwood procedure.

Linda M Lambert, Nancy A Pike, Barbara Medoff-Cooper, Victor Zak, Victoria L Pemberton, Lisa Young-Borkowski, Martha L Clabby, Kathryn N Nelson, Richard G Ohye, Bethany Trainor and 10 more

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Linda M LambertPrimary Children's Medical Center, Salt Lake City, UT. Electronic address: Linda.lambert@imail.org.
Nancy A PikeUniversity of California, Los Angeles, CA.
Barbara Medoff-CooperUniversity of Pennsylvania, School of Nursing, Children's Hospital of Philadelphia, Philadelphia, PA.
Victor ZakNew England Research Institutes, Watertown, MA.
Victoria L PembertonNational Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD.
Lisa Young-BorkowskiMedical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI.
Martha L ClabbyEmory University, Children's Healthcare of Atlanta, Atlanta, GA.
Kathryn N NelsonUniversity of Michigan, C. S. Mott Children's Hospital Congenital Heart Center, Ann Arbor, MI.
Richard G OhyeUniversity of Michigan School of Medicine, C. S. Mott Children's Hospital Congenital Heart Center, Ann Arbor, MI.
Bethany TrainorBoston Children's Hospital, Boston, MA.
Karen UzarkCincinnati Children's Hospital Medical Center, Cincinnati, OH.
Nancy RuddMedical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI.
Louise BannisterThe Hospital for Sick Children, Toronto, Ontario, Canada.
Rosalind KorsinColumbia University, New York, NY.
David S CooperCongenital Heart Institute of Florida, Orlando, FL.
Christian PizarroNemours Cardiac Center, Alfred I. duPont Hospital for Children, Wilmington, DE.
Sinai C ZyblewskiMedical University of South Carolina, Charleston, SC.
Bronwyn H BartleDuke University, Durham, NC.
Richard V WilliamsUniversity of Utah School of Medicine, Salt Lake City, UT.
Pediatric Heart Network Investigators

Funding

Pediatric Heart network DCCU10HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2011 to 2016
$44.9M
Ventricular Volumes and Varability (VVV)U01HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI SLEEPER, LYNN A · 2001 to 2010
$40.3M
Pediatric Heart Network: Follow-up of the Single Ventricle Reconstruction TrialU01HL068290 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAI, WYMAN W · 2001 to 2010
$4.1M
Pediatric Heart Disease Network: CHOP MembershipU01HL068279 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI VETTER, VICTORIA L · 2001 to 2010
$3.7M
Randomized Therapeutic Trials in Pediatric Heart DiseaseU01HL068285 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI NEWBURGER, JANE W. · 2001 to 2010
$3.4M
Randomized Clinical Trials for Pediatric Heart DiseaseU01HL068281 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SAUL, J PHILIP · 2001 to 2010
$3.2M
Clinical and genomic responses to remote ischemic preconditioningU01HL068288 · NHLBI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI MCCRINDLE, BRIAN W · 2001 to 2010
$3.0M
Intermountain Pediatric Heart Disease Research CenterU01HL068292 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN · 2001 to 2010
$2.7M
The Duke-UNC-CH Pediatric Cardiology Clinical CenterU01HL068269 · NHLBI · DUKE UNIVERSITY · PI LI, JENNIFER S · 2001 to 2010
$2.6M
Pediatric Heart Network Regents of the University of MichiganU10HL109737 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDBERG, CAREN S, OHYE, RICHARD G · 2011 to 2015
$2.3M
Pediatric Heart Network University of UtahU10HL109743 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN, WILLIAMS, RICHARD VINCENT · 2011 to 2015
$2.2M
Pediatric Heart Network Emory UniversityU10HL109781 · NHLBI · EMORY UNIVERSITY · PI BORDER, WILLIAM, MAHLE, WILLIAM T · 2011 to 2015
$1.7M
NHLBI NIH HHS HL068269NHLBI NIH HHS HL068270NHLBI NIH HHS HL068279NHLBI NIH HHS HL068281NHLBI NIH HHS HL068285NHLBI NIH HHS HL068288NHLBI NIH HHS HL068290NHLBI NIH HHS HL068292NHLBI NIH HHS HL085057NHLBI NIH HHS HL109737NHLBI NIH HHS HL109781NHLBI NIH HHS U01 HL068269NHLBI NIH HHS U01 HL068270NHLBI NIH HHS U01 HL068279NHLBI NIH HHS U01 HL068281NHLBI NIH HHS U01 HL068285NHLBI NIH HHS U01 HL068288NHLBI NIH HHS U01 HL068290NHLBI NIH HHS U01 HL068292NHLBI NIH HHS U01 HL085057NHLBI NIH HHS U10 HL068270NHLBI NIH HHS U10 HL109737NHLBI NIH HHS U10 HL109743NHLBI NIH HHS U10 HL109781
6 · The paper itself

Abstract

objectivesTo assess variation in feeding practice at hospital discharge after the Norwood procedure, factors associated with tube feeding, and associations among site, feeding mode, and growth before stage II. STUDY

designFrom May 2005 to July 2008, 555 subjects from 15 centers were enrolled in the Pediatric Heart Network Single Ventricle Reconstruction Trial; 432 survivors with feeding data at hospital discharge after the Norwood procedure were analyzed.

resultsDemographic and clinical variables were compared among 4 feeding modes: oral only (n = 140), oral/tube (n = 195), nasogastric tube (N-tube) only (n = 40), and gastrostomy tube (G-tube) only (n = 57). There was significant variation in feeding mode among sites (oral only 0%-81% and G-tube only 0%-56%, P < .01). After adjusting for site, multivariable modeling showed G-tube feeding at discharge was associated with longer hospitalization, and N-tube feeding was associated with greater number of discharge medications (R(2) = 0.65, P < .01). After adjusting for site, mean pre-stage II weight-for-age z-score was significantly higher in the oral-only group (-1.4) vs the N-tube-only (-2.2) and G-tube-only (-2.1) groups (P = .04 and .02, respectively).

conclusionsFeeding mode at hospital discharge after the Norwood procedure varied among sites. Prolonged hospitalization and greater number of medications at the time of discharge were associated with tube feeding. Infants exclusively fed orally had a higher weight-for-age z score pre-stage II than those fed exclusively by tube. Exploring strategies to prevent morbidities and promote oral feeding in this highest risk population is warranted.

Indexed as

Norwood ProceduresEnteral NutritionFemaleFollow-Up StudiesGastrostomyHumansHypoplastic Left Heart SyndromeInfant, NewbornLength of StayMalePatient DischargeRetrospective StudiesTreatment OutcomeWeight GainGastrostomy or gastrojejunostomy tubeG-tubeHLHSHypoplastic left heart syndromeNasojejunal or nasogastric tubeN-tubePediatric Heart Network Single Ventricle Reconstruction TrialPIPrincipal investigatorSVRWAZWeight-for-age z score

Identifiers

PMID24210923
PMCPMC3946861

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.