ArticleJournal of neuroimmunology2013
Relationship of plasma cytokines and clinical biomarkers to memory performance in HIV.
Article in Journal of neuroimmunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines.International journal of molecular sciences · 2020Pooled it
- Remitted depression and cognition in HIV: The role of cortisol and inflammation.Psychoneuroendocrinology · 2020Trial
- A single low dose of hydrocortisone enhances cognitive functioning in HIV-infected women.AIDS (London, England) · 2018Trial
- Cortical White and Grey Matter Volume Differences Associated with Plasma Cytokine and Chemokine Levels in PLWH in Cape Town.International journal of molecular sciences · 2025Article
- Plasma Inflammatory Biomarkers Link to Worse Cognition Among Africans With HIV.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- The Impact of COVID-19 on People Living with HIV-1 and HIV-1-Associated Neurological Complications.Viruses · 2023Review
- The association of peripheral immune markers with brain cortical thickness and surface area in South African people living with HIV.Journal of neurovirology · 2020Article
- The Association of Immune Markers with Cognitive Performance in South African HIV-Positive Patients.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Article
- Learning and Memory Impairments in Patients with Minimal Hepatic Encephalopathy are Associated with Structural and Functional Connectivity Alterations in Hippocampus.Scientific reports · 2018Article
- Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study.Journal of neurovirology · 2018Article
- Peripheral TNFα elevations in abstinent alcoholics are associated with hepatitis C infection.PloS one · 2018Article
- Childhood maltreatment and HIV-associated neurocognitive disorders share similar pathophysiology: a potential sensitisation mechanism?Metabolic brain disease · 2017Review
- Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition.Brain, behavior, and immunity · 2017Article
- Brief Report: CD14+ Enriched Peripheral Cells Secrete Cytokines Unique to HIV-Associated Neurocognitive Disorders.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Immune activation and neuroinflammation in alcohol use and HIV infection: evidence for shared mechanisms.The American journal of drug and alcohol abuse · 2017Review
- Factors related to HIV-associated neurocognitive impairment differ with age.Journal of neurovirology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Chronic systemic immune activation and inflammatory processes have been linked to brain dysfunction in medically stable HIV-infected people. We investigated the association between verbal memory performance and plasma concentrations of 13 cytokines measured using multiplexed bead array immunoassay in 74 HIV-seropositive individuals and 50 HIV-seronegative controls. Memory performance was positively related to levels of IL-8 and IFN-γ, and negatively related to IL-10 and IL-18 and to hepatitis C infection. Memory performance was not significantly related to HIV disease markers. The results indicate the importance of systemic immune and inflammatory markers to neurocognitive function in chronic and stable HIV disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.