ArticleCurrent biology : CB2013
A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Systematic identification of Oct4 transcriptional targets in embryonic stem cells using the auxin-inducible degron system and nascent RNA sequencing.Cell regeneration (London, England) · 2025Article
- Shared features of blastula and neural crest stem cells evolved at the base of vertebrates.Nature ecology & evolution · 2024Article
- Article
- A single-cell, time-resolved profiling ofScience advances · 2023Article
- Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency.Nature communications · 2022Article
- Review
- The functional diversity of the POUV-class proteins across vertebrates.Open biology · 2022Review
- Cadherins in early neural development.Cellular and molecular life sciences : CMLS · 2021Review
- Acellular Biologic Nipple-Areolar Complex Graft:Tissue engineering. Part A · 2020Article
- Chromatin accessibility and histone acetylation in the regulation of competence in early development.Developmental biology · 2020Article
- N-cadherin stabilises neural identity by dampening anti-neural signals.Development (Cambridge, England) · 2019Article
- Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2.eLife · 2017Article
- Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?PloS one · 2017Article
- Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation.BMC developmental biology · 2015Article
- Primordial germ cells: the first cell lineage or the last cells standing?Development (Cambridge, England) · 2015Review
- microRNA-103/107 Family Regulates Multiple Epithelial Stem Cell Characteristics.Stem cells (Dayton, Ohio) · 2015Article
- A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling.Stem cells (Dayton, Ohio) · 2015Article
- Genome-wide view of TGFβ/Foxh1 regulation of the early mesendoderm program.Development (Cambridge, England) · 2014Article
- Do all roads lead to Oct4? the emerging concepts of induced pluripotency.Trends in cell biology · 2014Review
- Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus.Development (Cambridge, England) · 2014Article
Corrections and comments
- Commented on by
Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundThe class V POU domain transcription factor Oct4 (Pou5f1) is a pivotal regulator of embryonic stem cell (ESC) self-renewal and reprogramming of somatic cells to induced pluripotent stem (iPS) cells. Oct4 is also an important evolutionarily conserved regulator of progenitor cell differentiation during embryonic development.
resultsHere we examine the function of Oct4 homologs in Xenopus embryos and compare this to the role of Oct4 in maintaining mammalian embryo-derived stem cells. Based on a combination of expression profiling of Oct4/POUV-depleted Xenopus embryos and in silico analysis of existing mammalian Oct4 target data sets, we defined a set of evolutionary-conserved Oct4/POUV targets. Most of these targets were regulators of cell adhesion. This is consistent with Oct4/POUV phenotypes observed in the adherens junctions in Xenopus ectoderm, mouse embryonic, and epiblast stem cells. A number of these targets could rescue both Oct4/POUV phenotypes in cellular adhesion and multipotent progenitor cell maintenance, whereas expression of cadherins on their own could only transiently support adhesion and block differentiation in both ESC and Xenopus embryos.
conclusionsCurrently, the list of Oct4 transcriptional targets contains thousands of genes. Using evolutionary conservation, we identified a core set of functionally relevant factors that linked the maintenance of adhesion to Oct4/POUV. We found that the regulation of adhesion by the Oct4/POUV network occurred at both transcriptional and posttranslational levels and was required for pluripotency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.