Evidence map›Paper›PMID 24210434›Full record

ArticleCurrent topics in membranes2013

"Cell biology meets physiology: functional organization of vertebrate plasma membranes"--the immunological synapse.

Silvia Curado, Sudha Kumari, Michael L Dustin

Open access · greenAbstract read
In one paragraph

Article in Current topics in membranes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Silvia CuradoSkirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, USA; Department of Pathology, New York University School of Medicine, New York, USA; Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Headington, Oxfordshire, Oxford, UK. Electronic address: silvia.curado@med.nyu.edu.
Sudha Kumari
Michael L Dustin
University of Oxford · GBNew York University · US

Funding

Nanomedicine development center for mechanobiologyPN2EY016586 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2005 to 2014
$23.0M
Requirement for Sensitive T Cell Response to AntigenR37AI043542 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2007 to 2016
$3.6M
NEI NIH HHS PN2 EY016586NIAID NIH HHS R37 AI043542
6 · The paper itself

Abstract

The immunological synapse (IS) is an excellent example of cell-cell communication, where signals are exchanged between two cells, resulting in a well-structured line of defense during adaptive immune response. This process has been the focus of several studies that aimed at understanding its formation and subsequent events and has led to the realization that it relies on a well-orchestrated molecular program that only occurs when specific requirements are met. The development of more precise and controllable T cell activation systems has led to new insights including the role of mechanotransduction in the process of formation of the IS and T cell activation. Continuous advances in our understanding of the IS formation, particularly in the context of T cell activation and differentiation, as well the development of new T cell activation systems are being applied to the establishment and improvement of immune therapeutical approaches.

Indexed as

AnimalsCell CommunicationCell DifferentiationCell MembraneImmunological SynapsesImmunotherapyLeukemia, MyeloidMechanotransduction, CellularReceptors, Antigen, T-CellSignal TransductionT-LymphocytesVertebratesReceptors, Antigen, T-CellActivationAdaptive responseMechanotransductionpMHCSignalingT cell

Identifiers

PMID24210434
PMCPMC4878826
OpenAlexW2407923203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.