ArticleDrug and alcohol dependence2014
Default mode network activity in male adolescents with conduct and substance use disorder.
Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Pooled it
- The effect of alcohol consumption on the adolescent brain: A systematic review of MRI and fMRI studies of alcohol-using youth.NeuroImage. Clinical · 2014Pooled it
- Neurobiological Mechanisms of Action of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Substance Use Disorders (SUDs)-A Review.Journal of clinical medicine · 2025Review
- Atypical functional connectome is associated with low reflective functioning in incarcerated adolescents.Frontiers in psychiatry · 2024Article
- Emotional and behavioral problems change the development of cerebellar gray matter volume, thickness, and surface area from childhood to adolescence: A longitudinal cohort study.CNS neuroscience & therapeutics · 2023Article
- Antisocial behavior is associated with reduced frontoparietal network efficiency in youth.Social cognitive and affective neuroscience · 2023Article
- Through the looking glass: the neural basis of self-concept in young adults with antisocial trajectories.Social cognitive and affective neuroscience · 2023Article
- Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth.NeuroImage. Clinical · 2023Article
- Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.Current behavioral neuroscience reports · 2022Article
- Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling.Molecular psychiatry · 2022Article
- Construction and Multiple Feature Classification Based on a High-Order Functional Hypernetwork on fMRI Data.Frontiers in neuroscience · 2022Article
- Decreased interhemispheric resting-state functional connectivity in male adolescents with conduct disorder.Brain imaging and behavior · 2021Article
- Alcohol use disorder and cannabis use disorder symptomatology in adolescents is associated with dysfunction in neural processing of future events.Addiction biology · 2021Article
- The associations of comorbid substance use disorders and psychiatric conditions with adolescent brain structure and function: A review.Journal of the neurological sciences · 2020Review
- Clarifying the Link Between Amygdala Functioning During Emotion Processing and Antisocial Behaviors Versus Callous-Unemotional Traits Within a Population-Based Community Sample.Clinical psychological science : a journal of the Association for Psychological Science · 2020Article
- Regional Homogeneity Abnormalities in Early-Onset and Adolescent-Onset Conduct Disorder in Boys: A Resting-State fMRI Study.Frontiers in human neuroscience · 2019Article
- Migraine in the Young Brain: Adolescents vs. Young Adults.Frontiers in human neuroscience · 2019Article
- Contributions of default mode network stability and deactivation to adolescent task engagement.Scientific reports · 2018Article
- MAOA genotype influences neural response during an inhibitory task in adolescents with conduct disorder.European child & adolescent psychiatry · 2018Article
- Conduct Disorder Symptoms and Illicit Drug Use in Juvenile Justice Involved Youth: The Reciprocal Relationship Between Positive Illicit Drug-Use Attitudes and Illicit Drug Use.Substance use & misuse · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAdolescents with conduct disorder (CD) and substance use disorders (SUD) experience difficulty evaluating and regulating their behavior in anticipation of future consequences. Given the role of the brain's default mode network (DMN) in self-reflection and future thought, this study investigates whether DMN is altered in adolescents with CD and SUD, relative to controls.
methodsTwenty adolescent males with CD and SUD and 20 male controls of similar ages underwent functional magnetic resonance imaging as they completed a risk-taking decision task. We used independent component analysis as a data-driven approach to identify the DMN spatial component in individual subjects. DMN activity was then compared between groups.
resultsCompared to controls, patients showed reduced activity in superior, medial and middle frontal gyrus (Brodmann area (BA) 10), retrosplenial cortex (BA 30) and lingual gyrus (BA 18), and bilateral middle temporal gryus (BA 21/22) - DMN regions thought to support self-referential evaluation, memory, foresight, and perspective taking. Furthermore, this pattern of reduced activity in patients remained robust after adjusting for the effects of depression and attention-deficit hyperactivity disorder (ADHD). Conversely, when not adjusting for effects of depression and ADHD, patients demonstrated greater DMN activity than controls solely in the cuneus (BA 19).
conclusionsCollectively, these results suggest that comorbid CD and SUD in adolescents is characterized by atypical activity in brain regions thought to play an important role in introspective processing. These functional imbalances in brain networks may provide further insight into the neural underpinnings of conduct and substance use disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.