Evidence map›Paper›PMID 24210173›Full record

ArticleMolecular cell2013

PAF makes it EZ(H2) for β-catenin transactivation.

Xinjun Zhang, Xi He

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xinjun ZhangF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Xi He
Boston Children's Hospital · US

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
Wnt-LRP interaction in Wnt signal transductionR01GM057603 · NIGMS · CHILDREN'S HOSPITAL BOSTON · PI HE, XI · 1999 to 2018
$6.3M
Genetic and Chemical Biological Studies of a Novel Wnt Inhibitor Tiki2R01AR060359 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI HE, XI · 2011 to 2015
$2.8M
Wnt/beta-catenin signaling: phosphorylation regulation of Wnt receptor-Axin interR01GM074241 · NIGMS · CHILDREN'S HOSPITAL BOSTON · PI HE, XI · 2005 to 2013
$2.5M
NIAMS NIH HHS R01 AR060359NICHD NIH HHS P30 HD018655NIGMS NIH HHS R01 GM057603NIGMS NIH HHS R01 GM074241
6 · The paper itself

Abstract

In this issue of Molecular Cell, Park and colleagues (Jung et al., 2013) show that PAF (PCNA-associated factor) binds to and hyperactivates transcriptional function of β-catenin in colon cancer cells by recruiting EZH2 to the coactivator complex. PAF-β-catenin and PAF-PCNA interactions are competitive, raising the question of whether β-catenin might regulate PCNA-dependent DNA replication and repair.

Indexed as

Wnt Signaling PathwayAnimalsbeta CateninCarrier ProteinsDNA-Binding ProteinsEnhancer of Zeste Homolog 2 ProteinHumansPolycomb Repressive Complex 2beta CateninCarrier ProteinsDNA-Binding ProteinsEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanPCLAF protein, humanPolycomb Repressive Complex 2

Identifiers

PMID24210173
PMCPMC3848709
OpenAlexW2024006296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.