Evidence map›Paper›PMID 24210169›Full record

ReviewJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)2014

Behavioral effects of developmental methylmercury drinking water exposure in rodents.

Emily B Bisen-Hersh, Marcelo Farina, Fernando Barbosa, Joao B T Rocha, Michael Aschner

Abstract readReview
In one paragraph

Review in Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. High level of methylmercury exposure causes persisted toxicity in Nauphoeta cinerea.Environmental science and pollution research international · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily B Bisen-HershDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: emily.bisen-hersh@vanderbilt.edu.
Marcelo FarinaDepartamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Fernando BarbosaDepartment of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, São Paulo, Brazil.
Joao B T RochaDepartamento de Química, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.
Michael AschnerDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pharmacology, The Kennedy Center for Research on Human Development, and The Center for Molecular Toxicology, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Structural Biology Facility CoreP30ES000267 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 1985 to 2014
$20.3M
Mechanisms of Methylmercury Induced Neuron ToxicityR01ES007331 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 1996 to 2026
$10.6M
Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing BrainR01ES020852 · NIEHS · VANDERBILT UNIVERSITY · PI ASCHNER, MICHAEL · 2012 to 2016
$1.8M
NIEHS NIH HHS P30 ES000267NIEHS NIH HHS R01 ES007331NIEHS NIH HHS R01 ES020852NIEHS NIH HHS R01ES020852NIEHS NIH HHS R01 ES07331
6 · The paper itself

Abstract

Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed.

Indexed as

AnimalsBehavior, AnimalDrinking WaterEnvironmental ExposureFemaleMethylmercury CompoundsPregnancyPrenatal Exposure Delayed EffectsRodentiaDrinking WaterMethylmercury CompoundsBehaviorDevelopmental neurotoxicityLearningMercuryRodents

Identifiers

PMID24210169
PMCPMC3979511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.