Evidence map›Paper›PMID 24210164›Full record

ReviewTrends in immunology2014

Regulation of hematopoietic stem cells by bone marrow stromal cells.

Bryan A Anthony, Daniel C Link

Abstract readReview
In one paragraph

Review in Trends in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed.

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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bryan A AnthonyDepartment of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Daniel C LinkDepartment of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: dlink@dom.wustl.edu.

Funding

MOLECULAR ONCOLOGY TRAINING GRANTT32CA113275 · NCI · WASHINGTON UNIVERSITY · PI Matthew J Walter · 2006 to 2026
$5.7M
ROLE OF THE G-CSF RECEPTOR IN PROGENITOR MOBILIZATIONR01HL060772 · NHLBI · WASHINGTON UNIVERSITY · PI LINK, DANIEL C · 1999 to 2014
$3.9M
NCI NIH HHS T32 CA113275NHLBI NIH HHS HL60772NHLBI NIH HHS R01 HL060772
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) reside in specialized microenvironments (niches) in the bone marrow. The stem cell niche is thought to provide signals that support key HSC properties, including self-renewal capacity and long-term multilineage repopulation ability. The stromal cells that comprise the stem cell niche and the signals that they generate that support HSC function are the subjects of intense investigation. Here, we review the complex and diverse stromal cell populations that reside in the bone marrow and examine their contribution to HSC maintenance. We highlight recent data suggesting that perivascular chemokine CXC ligand (CXCL)12-expressing mesenchymal progenitors and endothelial cells are key cellular components of the stem cell niche in the bone marrow.

Indexed as

AnimalsBone MarrowCadherinsCell LineageCellular MicroenvironmentChemokine CXCL12HematopoiesisHematopoietic Stem CellsHumansHypoxiaMesenchymal Stem CellsStem Cell NicheCadherinsChemokine CXCL12CXCL12hematopoietic stem cellsmesenchymal stem cellsosteoblastsstem cell niche

Identifiers

PMID24210164
PMCPMC3947365

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.