ArticleBiophysical journal2013
Intracellular encoding of spatiotemporal guidance cues in a self-organizing signaling system for chemotaxis in Dictyostelium cells.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 37 citations in OpenAlex.
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- Persistent cell contacts enable E-cadherin/HMR-1- and PAR-3-based symmetry breaking within a developing C. elegans epithelium.Developmental cell · 2023Article
- Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis.Cell structure and function · 2023Article
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- A minimal computational model for three-dimensional cell migration.Journal of the Royal Society, Interface · 2019Article
- Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells.Journal of cell science · 2019Article
- Three-Dimensional Cell Geometry Controls Excitable Membrane Signaling in Dictyostelium Cells.Biophysical journal · 2019Article
- Quantitative analysis of sensitivity to a Wnt3a gradient in determination of the pole-to-pole axis of mitotic cells by using a microfluidic device.FEBS open bio · 2018Article
- Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells.Nature communications · 2018Article
- Rhythmicity and waves in the cortex of single cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Modeling random crawling, membrane deformation and intracellular polarity of motile amoeboid cells.PloS one · 2018Article
- Altering the threshold of an excitable signal transduction network changes cell migratory modes.Nature cell biology · 2017Article
- Fast-crawling cell types migrate to avoid the direction of periodic substratum stretching.Cell adhesion & migration · 2016Article
- Hybrid mechanosensing system to generate the polarity needed for migration in fish keratocytes.Cell adhesion & migration · 2016Article
- Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration.PLoS biology · 2016Article
- Image based validation of dynamical models for cell reorientation.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2015Article
- Spontaneous Behaviors and Wall-Curvature Lead to Apparent Wall Preference in Planarian.PloS one · 2015Article
- Comparison of adaptation motifs: temporal, stochastic and spatial responses.IET systems biology · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even in the absence of guidance cues, chemotactic cells are often spontaneously motile, which should accompany a spontaneous symmetry breaking inside the cells. A shallow chemoattractant gradient can induce these cells to move directionally without much change in cell morphology. As the gradient becomes steeper, the accuracy of chemotaxis increases. It is not clear how the steepness is expressed or encoded internally in the signaling network, which in turn coordinately activates the motile apparatus for chemotaxis. In Dictyostelium cells, self-organizing polarization activities in the signaling network have been reported. In this paper, we conducted a theoretical study of the response of this self-organizing system to guidance cues. Our analyses indicate that self-organizing systems respond sharply to a shallow external gradient by increasing the precision of polarity direction and modulating the frequency of self-polarization. We also show how the precision increase and frequency modulation are achieved. Our results indicate that self-organizing activity, independent of external cues, is the basis for the sensitive and robust response to shallow gradients. Finally, we show that the system can sense the direction of space-time waves of a stimulus, for which Dictyostelium cells exhibit chemotaxis in the developmental process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.