ArticleBiophysical journal2013
Populational heterogeneity vs. temporal fluctuation in Escherichia coli flagellar motor switching.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Steady-state running rate sets the speed and accuracy of accumulation of swimming bacteria.Biophysical journal · 2022Article
- The Architectural Dynamics of the Bacterial Flagellar Motor Switch.Biomolecules · 2020Review
- Observation and Control of Gene Expression Noise: Barrier Crossing Analogies Between Drug Resistance and Metastasis.Frontiers in genetics · 2020Article
- Phenotypic diversity and temporal variability in a bacterial signaling network revealed by single-cell FRET.eLife · 2017Article
- Osmotaxis inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Gearbox of the Bacterial Flagellar Motor Switch.Structure (London, England : 1993) · 2016Article
- Response thresholds in bacterial chemotaxis.Science advances · 2015Article
- Understanding the link between single cell and population scale responses of Escherichia coli in differing ligand gradients.Computational and structural biotechnology journal · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
The dynamic switching of the bacterial flagellar motor regulates cell motility in bacterial chemotaxis. It has been reported under physiological conditions that the switching bias of the flagellar motor undergoes large temporal fluctuations, which reflects noise propagating in the chemotactic signaling network. On the other hand, nongenetic heterogeneity is also observed in flagellar motor switching, as a large group of switching motors show different switching bias and frequency under the same physiological condition. In this work, we present simultaneous measurement of groups of Escherichia coli flagellar motor switching and compare them to long time recording of single switching motors. Consistent with previous studies, we observed temporal fluctuations in switching bias in long time recording experiments. However, the variability in switching bias at the populational level showed much higher volatility than its temporal fluctuation. These results suggested stable individuality in E. coli motor switching. We speculate that uneven expression of key regulatory proteins with amplification by the ultrasensitive response of the motor can account for the observed populational heterogeneity and temporal fluctuations.
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Registered trials
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