ArticleBiological psychiatry2014
The development of the neural substrates of cognitive control in adolescents with autism spectrum disorders.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Inhibitory Control in Autism Spectrum Disorders: Meta-analyses on Indirect and Direct Measures.Journal of autism and developmental disorders · 2022Pooled it
- Executive Function in High-Functioning Autism Spectrum Disorder: A Meta-analysis of fMRI Studies.Journal of autism and developmental disorders · 2020Pooled it
- Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder.Psychological medicine · 2020Pooled it
- Neuroanatomical phenotypes in mental illness: identifying convergent and divergent cortical phenotypes across autism, ADHD and schizophrenia.Journal of psychiatry & neuroscience : JPN · 2018Pooled it
- Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder.Journal of autism and developmental disorders · 2014Trial
- Abnormal functional connectivity of dynamic brain network in toddlers with autism and its correlation with symptoms.BMC psychiatry · 2026Article
- The Roles of Different Executive Functioning Skills in Early Mathematics Ability of Preschoolers With Autism.Journal of autism and developmental disorders · 2026Article
- ADHD polygenic risk predicts neural signatures of cognitive control: Evidence from midfrontal theta dynamics.Translational psychiatry · 2026Article
- Exploring atypical spatial-functional coupling in adolescent autism spectrum disorder: insights from neurodevelopment and transcriptomic architecture.Frontiers in neuroscience · 2026Article
- Midbrain hypoactivation and mesocortical hypoconnectivity in inhibitory control learning in autism.Brain communications · 2026Article
- Analysis of brain functional connectivity in children with autism spectrum disorder and sleep disorders: a fNIRS observational study.Frontiers in psychology · 2025Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Genetic Overlap Between Midfrontal Theta Signals and Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Longitudinal Twin Cohort.Biological psychiatry · 2023Article
- The effect of learning to drum on behavior and brain function in autistic adolescents.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder.Journal of neurodevelopmental disorders · 2022Article
- Repetitive transcranial magnetic stimulation for insomnia in patients with autism spectrum disorder: Study protocol for a randomized, double-blind, and sham-controlled clinical trial.Frontiers in psychiatry · 2022Article
- Dissociating motor impairment from five-choice serial reaction time task performance in a mouse model of Angelman syndrome.Frontiers in behavioral neuroscience · 2022Article
- Identifying Boys With Autism Spectrum Disorder Based on Whole-Brain Resting-State Interregional Functional Connections Using a Boruta-Based Support Vector Machine Approach.Frontiers in neuroinformatics · 2022Article
- Components of Executive Control in Autism Spectrum Disorder: A Functional Magnetic Resonance Imaging Examination of Dual-Mechanism Accounts.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAutism spectrum disorders (ASDs) involve impairments in cognitive control. In typical development (TYP), neural systems underlying cognitive control undergo substantial maturation during adolescence. Development is delayed in adolescents with ASD. Little is known about the neural substrates of this delay.
methodsWe used event-related functional magnetic resonance imaging and a cognitive control task involving overcoming a prepotent response tendency to examine the development of cognitive control in young (ages 12-15; n = 13 with ASD and n = 13 with TYP) and older (ages 16-18; n = 14 with ASD and n = 14 with TYP) adolescents with whole-brain voxelwise univariate and task-related functional connectivity analyses.
resultsOlder ASD and TYP showed reduced activation in sensory and premotor areas relative to younger ones. The older ASD group showed reduced left parietal activation relative to TYP. Functional connectivity analyses showed a significant age by group interaction with the older ASD group exhibiting increased functional connectivity strength between the ventrolateral prefrontal cortex and the anterior cingulate cortex, bilaterally. This functional connectivity strength was related to task performance in ASD, whereas that between dorsolateral prefrontal cortex and parietal cortex (Brodmann areas 9 and 40) was related to task performance in TYP.
conclusionsAdolescents with ASD rely more on reactive cognitive control, involving last-minute conflict detection and control implementation by the anterior cingulate cortex and ventrolateral prefrontal cortex, versus proactive cognitive control requiring processing by dorsolateral prefrontal cortex and parietal cortex. Findings await replication in larger longitudinal studies that examine their functional consequences and amenability to intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.