ArticleCell2013
The frustrated gene: origins of eukaryotic gene expression.
Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- RNA-binding proteins and ribonucleoproteins as determinants of immunity.Nature reviews. Immunology · 2026Review
- RNA binding by Periphilin plays an essential role in initiating silencing by the HUSH complex.Nucleic acids research · 2025Article
- Transcriptional coupling of telomeric retrotransposons with the cell cycle.Science advances · 2025Article
- RNA splicing: a split consensus reveals two major 5' splice site classes.Open biology · 2025Review
- Fantastic proteins and where to find them - histones, in the nucleus and beyond.Journal of cell science · 2024Review
- Evolutionary immunology to explore original antiviral strategies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Nucleosomes at the Dawn of Eukaryotes.Genome biology and evolution · 2024Review
- mRNA nuclear export: how mRNA identity features distinguish functional RNAs from junk transcripts.RNA biology · 2024Review
- Article
- There's Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines.Biomimetics (Basel, Switzerland) · 2023Article
- Soma-to-germline RNA communication.Nature reviews. Genetics · 2022Review
- Heterochromatin: did H3K9 methylation evolve to tame transposons?Genome biology · 2021Article
- RNA-binding proteins and RNA methylation in myeloid cells.Immunological reviews · 2021Review
- Retroelement origins of pre-mRNA splicing.Wiley interdisciplinary reviews. RNA · 2020Review
- Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom.Nucleic acids research · 2020Article
- Suppression ofFrontiers in plant science · 2020Article
- The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans.Viruses · 2019Review
- Old cogs, new tricks: the evolution of gene expression in a chromatin context.Nature reviews. Genetics · 2019Review
- Function and Evolution of Nematode RNAi Pathways.Non-coding RNA · 2019Review
- Coaching from the sidelines: the nuclear periphery in genome regulation.Nature reviews. Genetics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Eukarytotic gene expression is frustrated by a series of steps that are generally not observed in prokaryotes and are therefore not essential for the basic chemistry of transcription and translation. Their evolution may have been driven by the need to defend against parasitic nucleic acids.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.