ArticleBMC evolutionary biology2013
Genetic susceptibility to infectious disease in East African Shorthorn Zebu: a genome-wide analysis of the effect of heterozygosity and exotic introgression.
Article in BMC evolutionary biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 27 citations in OpenAlex.
- Genomic diversity of Cameroonian Gudali and Gudali-cross cattle.Scientific reports · 2025Article
- Serological profile of respiratory viruses in unvaccinated steers upon their arrival at Brazilian feedlot facilities.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Genomic heterozygosity is associated with parasite abundance, but the effects are not mediated by host condition.Evolutionary ecology · 2023Article
- Association of immune responses of Zebu and Holstein-Friesian cattle and resistance to mycobacteria in a BCG challenge model.Transboundary and emerging diseases · 2021Article
- Genetic Diversity and Signatures of Selection for Thermal Stress in Cattle and Other TwoFrontiers in genetics · 2021Article
- Food securers or invasive aliens? Trends and consequences of non-native livestock introgression in developing countries.Global food security · 2020Article
- Reflections on IDEAL: What we have learnt from a unique calf cohort study.Preventive veterinary medicine · 2020Review
- Genetic Diversity of Cameroon Cattle and a Putative Genomic Map for Resistance to Bovine Tuberculosis.Frontiers in genetics · 2020Article
- Cattle genome-wide analysis reveals genetic signatures in trypanotolerant N'Dama.BMC genomics · 2017Article
- Signatures of Selection for Environmental Adaptation and Zebu × Taurine Hybrid Fitness in East African Shorthorn Zebu.Frontiers in genetics · 2017Article
- The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants EmulsigenVeterinary microbiology · 2016Article
- Signatures of positive selection in East African Shorthorn Zebu: A genome-wide single nucleotide polymorphism analysis.Scientific reports · 2015Article
- African Indigenous Cattle: Unique Genetic Resources in a Rapidly Changing World.Asian-Australasian journal of animal sciences · 2015Article
- Variation and covariation in strongyle infection in East African shorthorn zebu calves.Parasitology · 2015Article
- Co-infections determine patterns of mortality in a population exposed to parasite infection.Science advances · 2015Article
- Genome-wide analysis reveals the ancient and recent admixture history of East African Shorthorn Zebu from Western Kenya.Heredity · 2014Article
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14 authors at 9 institutions in 5 countries.
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Abstract
backgroundPositive multi-locus heterozygosity-fitness correlations have been observed in a number of natural populations. They have been explained by the correlation between heterozygosity and inbreeding, and the negative effect of inbreeding on fitness (inbreeding depression). Exotic introgression in a locally adapted population has also been found to reduce fitness (outbreeding depression) through the breaking-up of co-adapted genes, or the introduction of non-locally adapted gene variants. In this study we examined the inter-relationships between genome-wide heterozygosity, introgression, and death or illness as a result of infectious disease in a sample of calves from an indigenous population of East African Shorthorn Zebu (crossbred Bos taurus x Bos indicus) in western Kenya. These calves were observed from birth to one year of age as part of the Infectious Disease in East African Livestock (IDEAL) project. Some of the calves were found to be genetic hybrids, resulting from the recent introgression of European cattle breed(s) into the indigenous population. European cattle are known to be less well adapted to the infectious diseases present in East Africa. If death and illness as a result of infectious disease have a genetic basis within the population, we would expect both a negative association of these outcomes with introgression and a positive association with heterozygosity.
resultsIn this indigenous livestock population we observed negative associations between heterozygosity and both death and illness as a result of infectious disease and a positive association between European taurine introgression and episodes of clinical illness.
conclusionWe observe the effects of both inbreeding and outbreeding depression in the East African Shorthorn Zebu, and therefore find evidence of a genetic component to vulnerability to infectious disease. These results indicate that the significant burden of infectious disease in this population could, in principle, be reduced by altered breeding practices.
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