ArticleBMC evolutionary biology2013
Evolutionary rate patterns of genes involved in the Drosophila Toll and Imd signaling pathway.
Article in BMC evolutionary biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
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- Innate Immune Response ofInternational journal of molecular sciences · 2023Article
- The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes.Genome biology and evolution · 2023Article
- Comparative Genomics of the Waterfowl Innate Immune System.Molecular biology and evolution · 2022Article
- A fat body transcriptome analysis of the immune responses of Rhodnius prolixus to artificial infections with bacteria.Parasites & vectors · 2022Article
- Integration of Transcriptomic and Proteomic Analyses Reveals New Insights into the Regulation of Immune Pathways in Midgut ofInsects · 2022Article
- Nitric Oxide-Induced Calcineurin A Mediates Antimicrobial Peptide Production Through the IMD Pathway.Frontiers in immunology · 2022Article
- Gene expression predictions and networks in natural populations supports the omnigenic theory.BMC genomics · 2020Article
- Distinct evolution of toll-like receptor signaling pathway genes in cetaceans.Genes & genomics · 2019Article
- Article
- Review
- Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila.Molecular biology and evolution · 2017Article
- Evolutionary patterns of Toll-like receptor signaling pathway genes in the Suidae.BMC evolutionary biology · 2016Article
- Evolutionary Rate Heterogeneity of Primary and Secondary Metabolic Pathway Genes in Arabidopsis thaliana.Genome biology and evolution · 2015Article
- Evolutionary genetics of insect innate immunity.Briefings in functional genomics · 2015Review
- Rapid molecular evolution across amniotes of the IIS/TOR network.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Recent insights into the evolution of innate viral sensing in animals.Current opinion in microbiology · 2014Review
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7 authors.
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Abstract
backgroundTo survive in a hostile environment, insects have evolved an innate immune system to defend against infection. Studies have shown that natural selection may drive the evolution of immune system-related proteins. Yet, how network architecture influences protein sequence evolution remains unclear. Here, we analyzed the molecular evolutionary patterns of genes in the Toll and Imd innate immune signaling pathways across six Drosophila genomes within the context of a functional network.
resultsBased on published literature, we identified 50 genes that are directly involved in the Drosophila Toll and Imd signaling pathways. Of those genes, only two (Sphinx1 and Dnr1) exhibited signals of positive selection. There existed a negative correlation between the strength of purifying selection and gene position within the pathway; the downstream genes were more conserved, indicating that they were subjected to stronger evolutionary constraints. Interestingly, there was also a significantly negative correlation between the rate of protein evolution and the number of regulatory microRNAs, implying that genes regulated by more miRNAs experience stronger functional constraints and therefore evolve more slowly.
conclusionTaken together, our results suggested that both network architecture and miRNA regulation affect protein sequence evolution. These findings improve our understanding of the evolutionary patterns of genes involved in Drosophila innate immune pathways.
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