Evidence map›Paper›PMID 24209458›Full record

Trial reportParkinsonism & related disorders2014

Effects of a formal exercise program on Parkinson's disease: a pilot study using a delayed start design.

A Park, D Zid, J Russell, A Malone, A Rendon, A Wehr, X Li

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Parkinsonism & related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Early implementation of intended exercise improves quality of life in Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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  6. Trial
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  8. Article
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  14. EEG hyperscanning in motor rehabilitation: a position paper.Journal of neuroengineering and rehabilitation · 2021
    Article
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  19. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

A ParkDepartment of Neurology, The Ohio State University, Columbus, OH 43210, USA. Electronic address: ariane.park@osumc.edu.
D ZidColumbus Health Works, Columbus, OH 43212, USA.
J RussellColumbus Health Works, Columbus, OH 43212, USA.
A MaloneDepartment of Neurology, The Ohio State University, Columbus, OH 43210, USA.
A RendonDepartment of Neurology, The Ohio State University, Columbus, OH 43210, USA.
A WehrCenter for Biostatistics, The Ohio State University, Columbus, OH 43210, USA.
X LiCenter for Biostatistics, The Ohio State University, Columbus, OH 43210, USA.
The Ohio State University · USOhio Department of Health · US

Funding

The Ohio State University Center for Clinical and Translational Science (UL1)UL1TR000090 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2012 to 2013
$7.9M
NCATS NIH HHS UL1 TR000090NCATS NIH HHS UL1TR000090
6 · The paper itself

Abstract

introductionParkinson's Disease (PD) is a progressive neurodegenerative disease. Increasing evidence shows that physical exercise is beneficial for motor and non-motor symptoms of PD, and animal models suggest that it may help slow progression of disease.

methodsUsing a randomized delayed-start design, 31 patients were randomized to an early start group (ESG) or a delayed start group (DSG) exercise program. The ESG underwent a rigorous formal group exercise program for 1 h, three days/week, for 48 weeks (November 2011-October 2012). The DSG participated in this identical exercise program from weeks 24-48. Outcome measures included the Unified Parkinson's Disease Rating Scale (UPDRS), Walking Test (get-up-and-go), Tinetti Mobility Test, PDQ-39 Questionnaire, and the Beck Depression Inventory.

resultsThere was minimal attrition in this study, with only one patient dropping out. Results did not show improvement in total UPDRS scores with early exercise. At week 48, the mean change from baseline total UPDRS score was 6.33 in the ESG versus 5.13 in the DSG (p = 0.58). However, patients randomized to the ESG scored significantly better on the Beck Depression Inventory, with a mean improvement of 1.07 points relative to those in the DSG (p = 0.04).

conclusionsThe findings demonstrate that long-term, group exercise programs are feasible in the Parkinson's disease population, with excellent adherence and minimal drop out. While the outcome measures used in our study did not provide strong evidence that exercise has a neuroprotective effect on motor function, earlier participation in a group exercise program had a significant effect on symptoms of depression.

Indexed as

AdultAgedExercise TherapyFemaleHumansMaleMiddle AgedParkinson DiseasePilot ProjectsSurveys and QuestionnairesTreatment OutcomeDepressionExerciseNeuroprotectionParkinson's diseaseTinetti

Identifiers

PMID24209458
PMCPMC4030674
OpenAlexW2145464938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.