ArticleEpilepsy research2013
Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats.
Article in Epilepsy research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- High Doses of Melatonin Induce Seizure-like Cortical Activity: Electrophysiological and Behavioral Evidence.ACS omega · 2026Article
- Cannabidiol potentiates phenobarbital effects in the control of pentylenetetrazole (PTZ)-induced epileptic seizures in neonate rats.Frontiers in pediatrics · 2025Article
- Plants, Pills, and the Brain: Exploring Phytochemicals and Neurological Medicines.International journal of plant, animal and environmental sciences · 2025Article
- Padsevonil suppresses seizures without inducing cell death in neonatal rats.Pharmacological reports : PR · 2024Article
- Cenobamate suppresses seizures without inducing cell death in neonatal rats.Epilepsy & behavior : E&B · 2024Article
- Anti-seizure medication-induced developmental cell death in neonatal rats is unaltered by history of hypoxia.Epilepsy research · 2024Article
- Effect of melatonin on sleep quality and EEG features in childhood epilepsy: a possible non-conventional treatment.Frontiers in neurology · 2023Article
- Melatonin's Benefits and Risks as a Therapy for Sleep Disturbances in the Elderly: Current Insights.Nature and science of sleep · 2022Review
- Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders.International journal of molecular sciences · 2021Review
- Age-dependent anticonvulsant actions of perampanel and brivaracetam in the methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) model of seizures in developing rats.Pharmacological reports : PR · 2021Article
- The Molecular Genetic Interaction Between Circadian Rhythms and Susceptibility to Seizures and Epilepsy.Frontiers in neurology · 2020Review
- Role of Melatonin Receptors in Hyperthermia-Induced Acute Seizure Model of Rats.Journal of molecular neuroscience : MN · 2019Article
- Preclinical safety and efficacy of cannabidivarin for early life seizures.Neuropharmacology · 2019Article
- Neuroprotective Action of the CB1/2 Receptor Agonist, WIN 55,212-2, against DMSO but Not Phenobarbital-Induced Neurotoxicity in Immature Rats.Neurotoxicity research · 2019Article
- Neonatal phenobarbital exposure disrupts GABAergic synaptic maturation in rat CA1 neurons.Epilepsia · 2018Article
- Anticonvulsant drug-induced cell death in the developing white matter of the rodent brain.Epilepsia · 2016Article
- Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats.Epilepsy & behavior : E&B · 2016Article
- Article
- Profile of anticonvulsant action of levetiracetam, tiagabine and phenobarbital against seizures evoked by DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in neonatal rats.European journal of pharmacology · 2014Article
- Ontogenic profile of seizures evoked by the beta-carboline DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in rats.European journal of pharmacology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Phenobarbital is the most commonly utilized drug for neonatal seizures. However, questions regarding safety and efficacy of this drug make it particularly compelling to identify adjunct therapies that could boost therapeutic benefit. One potential adjunct therapy is melatonin. Melatonin is used clinically in neonatal and pediatric populations, and moreover, it exerts anticonvulsant actions in adult rats. However, it has not been previously evaluated for anticonvulsant effects in neonatal rats. Here, we tested the hypothesis that melatonin would exert anticonvulsant effects, either alone, or in combination with phenobarbital. Postnatal day (P)7 rats were treated with phenobarbital (0-40mg/kg) and/or melatonin (0-80mg/kg) prior to chemoconvulsant challenge with pentylenetetrazole (100mg/kg). We found that melatonin significantly potentiated the anticonvulsant efficacy of phenobarbital, but did not exert anticonvulsant effects on its own. These data provide additional evidence for the further examination of melatonin as an adjunct therapy in neonatal/pediatric epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.