ArticleBJOG : an international journal of obstetrics and gynaecology2014
Fertility treatment, twin births, and unplanned pregnancies in women with eating disorders: findings from a population-based birth cohort.
Article in BJOG : an international journal of obstetrics and gynaecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Psychiatric vulnerability and the risk for unintended pregnancies, a systematic review and meta-analysis.BMC pregnancy and childbirth · 2022Pooled it
- Prevalence and phenotype of eating disorders in assisted reproduction: a systematic review.Reproductive health · 2022Pooled it
- Adverse Neonatal Outcomes Among Children Born to Mothers Eating Disorders: A Register-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Endocrine complications of anorexia nervosa.Journal of eating disorders · 2023Review
- IVF-induced pregnancy and early motherhood among women with a history of severe eating disorders.Frontiers in psychology · 2023Article
- Article
- Eating Disorders During Gestation: Implications for Mother's Health, Fetal Outcomes, and Epigenetic Changes.Frontiers in pediatrics · 2020Review
- Reproductive Outcomes Among Women with Eating Disorders or Disordered Eating Behavior: Does Methodological Approach Shape Research Findings?Journal of women's health (2002) · 2018Article
- Variation in reproductive outcomes of women with histories of bulimia nervosa, anorexia nervosa, or eating disorder not otherwise specified relative to the general population and closest-aged sisters.The International journal of eating disorders · 2018Article
- Eating Disorders and Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Observational
- Article
- Obstetric and gynecologic problems associated with eating disorders.The International journal of eating disorders · 2016Review
- Corrigendum.BJOG : an international journal of obstetrics and gynaecology · 2015Article
- Article
Corrections and comments
- Erratum issuedCorrigendum.2015
- Erratum issuedSteenweg-de Graaf, J [corrected to Steenweg-de Graaff, J]
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate fertility treatment, twin births, and unplanned pregnancies in pregnant women with eating disorders in a population-based sample.
designA longitudinal population-based birth cohort (Generation R).
settingRotterdam, the Netherlands. SAMPLE: Women from the Generation R study who reported a history of (recent or past) anorexia nervosa (n = 160), bulimia nervosa (n = 265), or both (n = 130), and a history of psychiatric disorders other than eating disorders (n = 1396) were compared with women without psychiatric disorders (n = 4367).
methodsWomen were compared on the studied outcomes using logistic regression. We performed crude and adjusted analyses (adjusting for relevant confounding factors).
main outcome measuresFertility treatment, twin births, unplanned pregnancies, and women's feelings towards unplanned pregnancies.
resultsRelative to women without psychiatric disorders, women with bulimia nervosa had increased odds (odds ratio, OR, 2.3; 95% confidence interval, 95% CI, 1.1-5.2) of having undergone fertility treatment. Women with all eating disorders had increased odds of twin births (anorexia nervosa, OR 2.7, 95% CI 1.0-7.7; bulimia nervosa, OR 2.7, 95% CI 1.1-6.6; anorexia and bulimia nervosa, OR 3.795% CI 1.3-10.7). Anorexia nervosa was associated with increased odds of unplanned pregnancies (OR 1.8, 95% CI 1.2-2.6) and mixed feelings about these pregnancies (adjusted OR 5.0, 95% CI 1.7-14.4). Pre-pregnancy body mass index did not explain the observed associations.
conclusionsEating disorders are associated with increased odds of receiving fertility treatment and twin births. Women with anorexia nervosa were more likely to have an unplanned pregnancy and have mixed feelings about the unplanned pregnancy. Fertility treatment specialists should be aware that both active and past eating disorders (both anorexia nervosa and bulimia nervosa) might underlie fertility problems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.