ArticleBiomacromolecules2013
Sensitization of transforming growth factor-β signaling by multiple peptides patterned on DNA nanostructures.
Article in Biomacromolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Functionalizing DNA origami to investigate and interact with biological systems.Nature reviews. Materials · 2023Article
- Engineering Cell Surface Function with DNA Origami.Advanced materials (Deerfield Beach, Fla.) · 2017Article
- DNA origami applications in cancer therapy.Cancer science · 2017Review
- Regulation on Toll-like Receptor 4 and Cell Barrier Function by Rab26 siRNA-loaded DNA Nanovector in Pulmonary Microvascular Endothelial Cells.Theranostics · 2017Article
- DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior.Advanced materials (Deerfield Beach, Fla.) · 2016Review
- In vitro selection technologies to enhance biomaterial functionality.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain.Protein expression and purification · 2015Article
- Comparative Incorporation of PNA into DNA Nanostructures.Molecules (Basel, Switzerland) · 2015Article
- Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons.Nano letters · 2015Article
- Utilizing multiscale engineered biomaterials to examine TGF-β-mediated myofibroblastic differentiation.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
We report sensitization of a cellular signaling pathway by addition of functionalized DNA nanostructures. Signaling by transforming growth factor β (TGFβ) has been shown to be dependent on receptor clustering. By patterning a DNA nanostructure with closely spaced peptides that bind to TGFβ receptor, we observe increased sensitivity of NMuMG cells to TGFβ ligand. This is evidenced by translocation of secondary messenger proteins to the nucleus and stimulation of an inducible luciferase reporter at lower concentrations of TGFβ ligand. We believe this represents an important initial step toward realization of DNA as a self-assembling and biologically compatible material for use in tissue engineering and drug delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.