ArticleAnnals of laboratory medicine2013
Random urinary calcium/creatinine ratio for screening hypercalciuria in children with hematuria.
Article in Annals of laboratory medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Normal Reference Range of the Urinary Calcium/Creatinine Ratio in Healthy Children.Indian journal of pediatrics · 2026Article
- German Clinical Practice Guideline on Microhematuria in Children and Young Adults: Evaluating Early Detection of Kidney Disease.Kidney international reports · 2026Article
- Acute oxalate nephropathy seven years post Roux-en-Y gastric bypass surgery without excessive vitamin C intake: a case report.BMC geriatrics · 2025Article
- Investigating the Prevalence of Hypercalciuria in Children Aged 2-16 Years With Asymptomatic Microscopic Hematuria in 2020 in Tehran Children's Medical Center.Clinical case reports · 2024Article
- Disease Manifestations and Complications in Dutch X-Linked Hypophosphatemia Patients.Calcified tissue international · 2024Article
- Urinary minerals excretion among primary schoolchildren in Dubai-United Arab Emirates.PloS one · 2021Article
- Spot urine samples to estimate 24-hour urinary calcium excretion in school-age children.European journal of pediatrics · 2020Article
- Approach to Persistent Microscopic Hematuria in Children.Kidney360 · 2020Review
- Measurement of preprandial and postprandial urine calcium to creatinine ratios in male Miniature Schnauzers with and without urolithiasis.Journal of veterinary internal medicine · 2020Article
- Evaluation of hypercalciuria in patients receiving intravenous Cefotaxime.Journal of family medicine and primary care · 2019Article
- The variation in urinary calcium levels in adult patients with fracture and surgical intervention.Journal of orthopaedic surgery and research · 2017Article
- Urinary calcium excretion in postmenopausal African American women.Clinical nephrology · 2015Article
- Normalisation of urinary biomarkers to creatinine for clinical practice and research--when and why.Singapore medical journal · 2015Article
- Urinary excretion of calcium, magnesium, phosphate, citrate, oxalate, and uric acid by healthy schoolchildren using a 12-h collection protocol.Pediatric nephrology (Berlin, Germany) · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypercalciuria is one of the most common causes of unexplained isolated hematuria. The diagnostic methods for hypercalciuria have not yet been standardized. The aim of this study was to assess whether random urinary calcium/creatinine ratio could be used as a screening tool for hypercalciuria in children with hematuria.
methodsThis prospective study included 264 children with primary hematuria for whom both random and 24 hr urinary evaluations were performed. Pearson correlation and ROC curve were used to assess the correlations. A multiple linear regression model was used to analyze effects of age, weight, height, body mass index, and body surface area on random urinary calcium/creatinine ratio.
resultsThere was a moderately strong correlation between random urinary calcium/creatinine ratio and 24 hr urinary calcium excretion (r=0.584, P<0.001). The most appropriate cutoff value of random urinary calcium/creatinine ratio for the estimation of hypercalciuria was 0.075 mg/mg (sensitivity, 77.8%; specificity, 64.3%; area under the curve, 0.778). Body mass index and 24 hr urinary calcium excretion significantly affected random urinary calcium/creatinine ratio with a low coefficient of determination (r(2)=0.380, P<0.001).
conclusionsRandom urinary calcium/creatinine ratio is not suitable for screening hypercalciuria in children with hematuria. Twenty-four hour urinary analysis should be performed to diagnose hypercalciuria in children with hematuria.
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