ArticlePloS one2013
Influence of Atg5 mutation in SLE depends on functional IL-10 genotype.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03583853 (Autophagy Genes and Interleukin-10 in Systemic Lupus Erythematosus Patients), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autophagy Genes and Interleukin-10 in Systemic Lupus Erythematosus Patients
Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study.Oral diseases · 2019Trial
- Autophagy, NET formation, and inflammation crosstalk in thrombotic autoimmune diseases.Frontiers in immunology · 2026Review
- Autophagy: a necessary evil in cancer and inflammation.3 Biotech · 2024Review
- Research progress of T cell autophagy in autoimmune diseases.Frontiers in immunology · 2024Review
- Association of ATG5 gene polymorphism with Parkinson's disease in a Han Chinese population.Acta neurologica Belgica · 2022Article
- The Role of Autophagy in the Function of CD4Frontiers in pharmacology · 2022Review
- Autophagy and Skin Diseases.Frontiers in pharmacology · 2022Review
- Gene polymorphisms inPeerJ · 2021Article
- Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes.International journal of molecular sciences · 2020Review
- Functional Genetic Variant in ATG5 Gene Promoter in Acute Myocardial Infarction.Cardiology research and practice · 2020Article
- Article
- The Therapeutic and Pathogenic Role of Autophagy in Autoimmune Diseases.Frontiers in immunology · 2018Review
- Association between genetic polymorphisms in the autophagy-related 5 gene promoter and the risk of sepsis.Scientific reports · 2017Article
- New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets.Autophagy · 2017Review
- Autophagy and autoimmunity.Clinical immunology (Orlando, Fla.) · 2017Review
- Autophagy in Dendritic Cells and B Cells Is Critical for the Inflammatory State of TLR7-Mediated Autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- A Variant of the Autophagy-Related 5 Gene Is Associated with Child Cerebral Palsy.Frontiers in cellular neuroscience · 2017Article
- Autophagy: controlling cell fate in rheumatic diseases.Nature reviews. Rheumatology · 2016Review
- Parkin Regulates Mitochondrial Autophagy After Myocardial Infarction in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.Nature · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence supports the involvement of autophagy in the etiopathology of autoimmune diseases. Despite the identification of autophagy-related protein (Atg)-5 as one of the susceptibility loci in systemic Lupus erythematosus (SLE), the consequences of the carriage of these mutations for patients remain unclear. The present work analyzed the association of Atg5 rs573775 single nucleotide polymorphism (SNP) with SLE susceptibility, IFNα, TNFα and IL-10 serum levels, and clinical features, in 115 patients and 170 healthy individuals. Patients who where carriers of the rs573775 T* minor allele presented lower IFNα levels than those with the wild genotype, whereas the opposite result was detected for IL-10. Thus, since IL-10 production was regulated by rs1800896 polymorphisms, we evaluated the effect of this Atg5 mutation in genetically high and low IL-10 producers. Interestingly, we found that the rs573775 T* allele was a risk factor for SLE in carriers of the high IL-10 producer genotype, but not among genetically low producers. Moreover, IL-10 genotype influences SLE features in patients presenting the Atg5 mutated allele. Specifically, carriage of the rs573775 T* allele led to IL-10 upregulation, reduced IFNα and TNFα production and a low frequency of cytopenia in patients with the high IL-10 producer genotype, whereas patients with the same Atg5 allele that were low IL-10 producers presented reduced amounts of all these cytokines, had a lower prevalence of anti-dsDNA antibodies and the latest onset age. In conclusion, the Atg5 rs573775 T* allele seems to influence SLE susceptibility, cytokine production and disease features depending on other factors such as functional IL-10 genotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.