SynthesisPloS one2013
The effects of postmenopausal hormone use on cataract: a meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Menopausal hormone therapy and women's health: An umbrella review.PLoS medicine · 2021Pooled it
- The national and subnational prevalence of cataract and cataract blindness in China: a systematic review and meta-analysis.Journal of global health · 2018Pooled it
- Hysterectomy for Benign Indications and Risk of Cataract Formation in South Korean Women.Medicina (Kaunas, Lithuania) · 2023Article
- Application of Andersen-Newman model to assess cataract surgery uptake among older Australian women: findings from the Australian Longitudinal Study on Women's Health (ALSWH).Aging clinical and experimental research · 2022Article
- Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea.Scientific reports · 2021Article
- Common causes of visual impairment in the elderly.Medical hypothesis, discovery & innovation ophthalmology journal · 2021Review
- Interaction between postmenopausal hormone therapy and diabetes on cataract.Menopause (New York, N.Y.) · 2020Article
- Changes in Retinal Structure and Ultrastructure in the Aged Mice Correlate With Differences in the Expression of Selected Retinal miRNAs.Frontiers in pharmacology · 2020Article
- Rosmarinic and Sinapic Acids May Increase the Content of Reduced Glutathione in the Lenses of Estrogen-Deficient Rats.Nutrients · 2019Article
- Development of topical ophthalmic In Situ gel-forming estradiol delivery system intended for the prevention of age-related cataracts.PloS one · 2017Article
- Risk Factors for Cataracts Treated Surgically in Postmenopausal Women.Ophthalmology · 2016Article
- Childbearing May Increase the Risk of Nondiabetic Cataract in Chinese Women's Old Age.Journal of ophthalmology · 2015Article
- The Association of Outdoor Activity and Age-Related Cataract in a Rural Population of Taizhou Eye Study: Phase 1 Report.PloS one · 2015Article
- Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration.Brain research bulletin · 2014Review
- Utilizing Data Mining Algorithms and Geospatial Analysis to Study Cataract Surgeries in Florida.Journal of current ophthalmologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCataract is the leading cause of blindness worldwide. Many observational studies assessed the relationship between postmenopausal hormone replacement therapy (HRT) and risk of cataract development, but the reported results were controversial. The aim of present meta-analysis was to evaluate the association of postmenopausal hormone replacement therapy with risk of cataract development.
methodsThe eligible observational studies, including cross-sectional, case-control and cohort studies, were identified by searching PubMed and Embase during March of 2013. Either a fixed- or a random-effects model was used to calculate the pooled odds ratio (OR) with its 95% confidence interval (95%CI). Subgroup analysis on cataract types was performed.
resultsA total of four cohort and five case-control or cross-sectional studies were finally included into this meta-analysis. Overall, a significant decreased risk of developing any type of cataract was found in ever HRT group as compared with non-HRT group among cohort studies (OR 0.83; 95%CI: 0.71,0.97) and case-control or cross-sectional studies (OR 0.74; 95%CI: 0.59,0.93). Subgroup analysis on cataract types determined that the significantly decreased risk of nuclear cataract in current HRT group (OR 0.72; 95%CI: 0.61,0.85) and also a critically reduced risk of nuclear cataract in ever HRT group (OR 0.80; 95% CI: 0.64,1.01) were found among case-control or cross-sectional studies, as compared with non-HRT group. No association of HRT with risk of cortical and posterior subcapsular cataract was observed.
conclusionsThe results of present meta-analysis indicate that postmenopausal hormone use may play a protective role in cataract development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.