ArticlePloS one2013
Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Pooled it
- Radiologic analysis of cavum septi pellucidi and cavum vergae in children.Surgical and radiologic anatomy : SRA · 2026Article
- The Development of Psychosis in Patients with Substance Use Disorder and Its Association with Cavum Septum Pellucidum and Adhesio Interthalamica.Psychiatry and clinical psychopharmacology · 2023Article
- Examining for Cavum Septum Pellucidum and Ventricular Enlargement in Retired Elite-Level Rugby League Players.Frontiers in neurology · 2022Article
- Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review.Acta neuropathologica communications · 2021Review
- Normal appearances and dimensions of the foetal cavum septi pellucidi and vergae on in utero MR imaging.Neuroradiology · 2020Article
- Cavum Septum Pellucidum in the General Pediatric Population and Its Relation to Surrounding Brain Structure Volumes, Cognitive Function, and Emotional or Behavioral Problems.AJNR. American journal of neuroradiology · 2019Article
- The relationship between cavum septum pellucidum and psychopathic traits in a large forensic sample.Neuropsychologia · 2018Article
- Prescription opioid use disorder and heroin use among 12-34 year-olds in the United States from 2002 to 2014.Addictive behaviors · 2017Article
- Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring.Neuropharmacology · 2016Article
- Cavum Septum Pellucidum in Retired American Pro-Football Players.Journal of neurotrauma · 2016Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveAdolescent-onset exposure to highly addictive substances such as opiates may induce far-reaching deleterious effects on later mental and physical health. However, little is known about the neurodevelopmental basis for adolescent-onset opiate dependence. Here we examined whether having an abnormally large cavum septum pellucidum (CSP), a putative marker of limbic structural maldevelopment, is associated with opiate dependence particularly beginning in adolescence.
methodThe overall length of the CSP and the prevalence of abnormal enlargement of the CSP were assessed and compared in 65 opiate-dependent subjects (41 adolescent-onset opiate users and 24 adult-onset opiate users) and 67 healthy subjects.
resultsOpiate-dependent subjects showed a greater prevalence of abnormal CSP enlargement relative to healthy subjects (odds ratio [OR]=3.64, p=0.034). The overall CSP length of adolescent-onset opiate-dependent subjects was greater, as compared not only with healthy subjects (F₁,₁₀₄=11.03, p=0.001) but also with those who began opiate use during adulthood (F₁,₆₁=4.43, p=0.039).
conclusionsThe current findings provide the first evidence that abnormal CSP enlargement, which reflects limbic system dysgenesis of neurodevelopmental origin, may be linked to later development of opiate dependence. In addition, a greater CSP length, which indicates more severe limbic abnormalities, appears to confer higher risk for earlier onset of opiate use.
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