ArticlePloS one2013
Impact of a single phage and a phage cocktail application in broilers on reduction of Campylobacter jejuni and development of resistance.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 119 citations in OpenAlex.
- Sources, Transmission, and Control of Salmonella in Vertically Integrated Broiler Chicken Production: Farm, Hatchery, and Processing Plant.Comprehensive reviews in food science and food safety · 2026Review
- Assessing the impact of phage therapy on growth performance, microbiome and phage specific immune response in chickens.Scientific reports · 2026Article
- Effectiveness of Interventions and Control Measures in the Reduction ofFoods (Basel, Switzerland) · 2026Review
- Broad-spectrum phage cocktail targetingFrontiers in microbiology · 2026Article
- A Comprehensive Review of the Application of Bacteriophages Against Enteric Bacterial Infection in Poultry: Current Status, Challenges, and Future Prospects.Antibiotics (Basel, Switzerland) · 2025Review
- A Rational Approach to Developing a Phage Biopreparation: Boosting Lytic Efficiency and Countering Resistance in Pathogenic Escherichia coli.Bulletin of experimental biology and medicine · 2025Article
- Efficiency, cytotoxicity, and survivability evaluation ofVeterinary world · 2025Article
- Isolation and characterization of novel lytic bacteriophages against (fluoro)quinolone-resistantFrontiers in microbiology · 2025Article
- Antibacterial efficacy of mycobacteriophages against virulent Mycobacterium tuberculosis.BMC microbiology · 2024Article
- Combined application of bacteriophages with a competitive exclusion culture and carvacrol with organic acids can reduce Campylobacter in primary broiler production.Scientific reports · 2024Article
- Collateral sensitivity increases the efficacy of a rationally designed bacteriophage combination to controlJournal of virology · 2024Article
- Investigating bacteriophages as a novel multiple-hurdle measure against Campylobacter: field trials in commercial broiler plants.Scientific reports · 2024Article
- SW16-7, a NovelMicroorganisms · 2023Article
- Bacteriophage cocktail application for Campylobacter mitigation - from in vitro to in vivo.BMC microbiology · 2023Article
- Bacteriophages for the Targeted Control of Foodborne Pathogens.Foods (Basel, Switzerland) · 2023Review
- Decolonizing drug-resistantMicrobiology (Reading, England) · 2023Article
- Review
- Antimicrobial Drug Resistance in Poultry Production: Current Status and Innovative Strategies for Bacterial Control.Microorganisms · 2023Review
- Disarm The Bacteria: What Temperate Phages Can Do.Current issues in molecular biology · 2023Review
- Intervention Strategies to ControlMicroorganisms · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacteriosis is currently the most frequent foodborne zoonosis in many countries. One main source is poultry. The aim of this study was to enhance the knowledge about the potential of bacteriophages in reducing colonization of broilers with Campylobacter , as there are only a few in vivo studies published. Commercial broilers were inoculated with 10⁴ CFU/bird of a Campylobacter jejuni field strain. Groups of 88 birds each were subsequently treated with a single phage or a four-phage cocktail (10⁷ PFU/bird in CaCO₃ buffered SM-Buffer). Control birds received the solvent only. Afterwards, subgroups of eleven birds each were examined for their loads with phages and Campylobacter on day 1, 3, 7, 14, 21, 28, 35 and 42 after phage application. The susceptibility of the Campylobacter population to phage infection was determined using ten isolates per bird. In total 4180 re-isolates were examined. The study demonstrated that the deployed phages persisted over the whole investigation period. The Campylobacter load was permanently reduced by the phage-cocktail as well as by the single phage. The reduction was significant between one and four weeks after treatment and reached a maximum of log₁₀ 2.8 CFU/g cecal contents. Phage resistance rates of initially up to 43% in the single phage treated group and 24% in the cocktail treated group later stabilized at low levels. The occurrence of phage resistance influenced but did not override the Campylobacter reducing effect. Regarding the reduction potential, the cocktail treatment had only a small advantage over the singe phage treatment directly after phage administration. However, the cocktail moderated and delayed the emergence of phage resistance.
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Registered trials
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