ArticlePloS one2013
Maternal malnutrition and offspring sex determine juvenile obesity and metabolic disorders in a swine model of leptin resistance.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice.Nature communications · 2024Article
- Gestational Caloric Restriction Alters Adipose Tissue Methylome and Offspring's Metabolic Profile in a Swine Model.International journal of molecular sciences · 2024Article
- Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin.Biology · 2022Article
- Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Prenatal Effects on Fetal Fatty Acid Composition in the Iberian Pig.Animals : an open access journal from MDPI · 2022Article
- Metabolic programming in the offspring after gestational overfeeding in the mother: toward neonatal rescuing with metformin in a swine model.International journal of obesity (2005) · 2022Article
- Article
- The Effects of Maternal Metformin Treatment on Late Prenatal and Early Postnatal Development of the Offspring Are Modulated by Sex.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring.Animals : an open access journal from MDPI · 2020Article
- Article
- Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Differential Effects of Litter Size and Within-Litter Birthweight on Postnatal Traits of Fatty Pigs.Animals : an open access journal from MDPI · 2020Article
- The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndrome.International journal of obesity (2005) · 2020Article
- Article
- Effects of Dietary Taurine Supplementation to Gilts during Late Gestation and Lactation on Offspring Growth and Oxidative Stress.Animals : an open access journal from MDPI · 2019Article
- Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study.International journal of reproductive biomedicine · 2018Article
- Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity.International journal of molecular sciences · 2018Article
- Maternal undernutrition and offspring sex determine birth-weight, postnatal development and meat characteristics in traditional swine breeds.Journal of animal science and biotechnology · 2018Article
- The Risks of Overweight, Obesity and Abdominal Obesity in Middle Age after Exposure to Famine in Early Life: Evidence from the China's 1959-1961 Famine.The journal of nutrition, health & aging · 2018Article
- Non-invasive methods for the determination of body and carcass composition in livestock: dual-energy X-ray absorptiometry, computed tomography, magnetic resonance imaging and ultrasound: invited review.Animal : an international journal of animal bioscience · 2015Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to determine, in a swine model of leptin resistance, the effects of type and timing of maternal malnutrition on growth patterns, adiposity and metabolic features of the progeny when exposed to an obesogenic diet during their juvenile development and possible concomitant effects of the offspring sex. Thus, four groups were considered. A CONTROL group involved pigs born from sows fed with a diet fulfilling their daily maintenance requirements for pregnancy. The treated groups involved the progeny of females fed with the same diet but fulfilling either 160% or 50% of pregnancy requirements during the entire gestation (OVERFED and UNDERFED, respectively) or 100% of requirements until Day 35 of pregnancy and 50% of such amount from Day 36 onwards (LATE-UNDERFED). OVERFED and UNDERFED offspring were more prone to higher corpulence and fat deposition from early postnatal stages, during breast-feeding; adiposity increased significantly when exposed to obesogenic diets, especially in females. The effects of sex were even more remarkable in LATE-UNDERFED offspring, which had similar corpulence to CONTROL piglets; however, females showed a clear predisposition to obesity. Furthermore, the three groups of pigs with maternal malnutrition showed evidences of metabolic syndrome and, in the case of individuals born from OVERFED sows, even of insulin resistance and the prodrome of type-2 diabetes. These findings support the main role of early nutritional programming in the current rise of obesity and associated diseases in ethnics with leptin resistance.
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