ArticlePloS one2013
Analysis of factors contributing to the low survival of cervical cancer patients undergoing radiotherapy in Kenya.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Digital Health Strategies for Cervical Cancer Control in Low- and Middle-Income Countries: Systematic Review of Current Implementations and Gaps in Research.Journal of medical Internet research · 2021Pooled it
- Cervical cancer prevention and treatment research in Africa: a systematic review from a public health perspective.BMC women's health · 2016Pooled it
- Differences in Outcomes of Chemoradiation in Women With Invasive Cervical Cancer by Human Immunodeficiency Virus Status: A Systematic Review.Practical radiation oncologyPooled it
- Population-based utility scores for HPV infection and cervical squamous cell carcinoma among Australian Indigenous women.PloS one · 2021Trial
- Trial
- Burden and predictors of cervical cancer mortality in Sub-Saharan Africa: a systematic review and meta-analysis.Infectious agents and cancer · 2026Review
- Observational
- Rural-urban variations in cervical cancer screening uptake among women in Ghana: Evidence from the 2022 Ghana Demographic and Health Survey.BMC women's health · 2025Article
- Article
- Review
- Development of a customized m-Health-based intervention to reduce loss to follow-up among patients undergoing treatment for cervical lesions at a rural referral Hospital, South Western Uganda.Gynecologic oncology reports · 2024Article
- Cervical cancer management in a low resource setting: A 10-year review in a tertiary care hospital in Kenya.Gynecologic oncology reports · 2024Article
- "It was not normal, and I had to find a doctor and tell him." Kenyan Women's Response to Cervical Cancer Symptoms.Journal of patient experience · 2024Article
- Survival Status and Predictors Among Women with Advanced Stage of Cervical Cancer.International journal of women's health · 2024Article
- Epidemiology and survival outcomes of HIV-associated cervical cancer in Nigeria.Infectious agents and cancer · 2023Article
- Implementing Smartphone-Based Telemedicine for Cervical Cancer Screening in Uganda: Qualitative Study of Stakeholders' Perceptions.Journal of medical Internet research · 2023Article
- Preferences for Breast and Cervical Cancer Screening Among Women and Men in Kenya: Key Considerations for Designing Implementation Strategies to Increase Screening Uptake.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023Article
- HPV genotypes in high-grade cervical lesions and invasive cervical carcinoma detected in Gabonese women.Infectious agents and cancer · 2023Article
- Clinical and non-clinical determinants of cervical cancer mortality: A retrospective cohort study in Lagos, Nigeria.Frontiers in oncology · 2023Article
- Prevention of Cervical Cancer in Low-Resource African Settings.Obstetrics and gynecology clinics of North America · 2022Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn contrast to the developed nations, invasive cervical cancer (ICC) is the most common womens malignancy in Kenya and many other locations in sub-Saharan Africa. However, studies on survival from this disease in this area of the world are severely restricted by lack of patient follow-up. We now report a prospective cohort study of ICC in Kenyan women analysing factors affecting tumour response and overall survival in patients undergoing radiotherapy. METHODS AND
findingsBetween 2008 and 2010, 355 patients with histologically confirmed ICC were recruited at the Departments of Gynaecology and Radiotherapy at Kenyatta National Hospital (KNH). Structured questionnaires were completed recording socio-demographics, tumour response and overall survival following treatment with combinations of external beam radiation (EBRT), brachytherapy and adjuvant chemotherapy. Of the 355 patients, 42% (146) were lost to follow-up while 18% (64) died during the two year period. 80.5% of patients presented with advanced stage IIB disease or above, with only 6.7% of patients receiving optimal combined EBRT, brachytherapy and adjuvant chemotherapy. Kaplan Meier survival curves projected two year survival at <20%.
conclusionCervical cancer is preventable yet poverty, poor education, lack of cancer awareness coupled with an absence of regular screening programs, late patient presentation, sub-optimal diagnosis and treatments are major factors contributing to the alarmingly low survival rate of cervical cancer patients in Kenya. It is concluded that simple cost-effective changes in clinical practice could be introduced which would have a marked impact on patient survival in this setting.
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