ArticlePloS one2013
Osteological and biomolecular evidence of a 7000-year-old case of hypertrophic pulmonary osteopathy secondary to tuberculosis from neolithic hungary.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 81 citations in OpenAlex.
- Infectious Spondylodiscitis of Bacterial Causes in Adults: Epidemiology, Pathophysiology, Diagnostic and Treatment Challenges.Microorganisms · 2026Review
- Modelling cultural responses to disease spread in Neolithic Trypillia mega-settlements.Journal of the Royal Society, Interface · 2024Article
- Parallel signatures of Mycobacterium tuberculosis and human Y-chromosome phylogeography support the Two Layer model of East Asian population history.Communications biology · 2023Article
- Construction of a Bacterial Lipidomics Analytical Platform: Pilot Validation with Bovine Paratuberculosis Serum.Metabolites · 2023Article
- Silicosis and silicotuberculosis: Ancient diseases that are still not conquered.African journal of thoracic and critical care medicine · 2023Article
- The Evolution of Diagnostic Techniques in the Paleopathology of Tuberculosis: A Scoping Review.Pathogens & immunity · 2023Article
- Biodiversity ofMicroorganisms · 2022Article
- A seventeenth-century Mycobacterium tuberculosis genome supports a Neolithic emergence of the Mycobacterium tuberculosis complex.Genome biology · 2020Article
- The past, present and future of ancient bacterial DNA.Microbial genomics · 2020Review
- Screening methods for detection of ancient Mycobacterium tuberculosis complex fingerprints in next-generation sequencing data derived from skeletal samples.GigaScience · 2019Article
- Chest pain in a young immunocompetent male: A rare case scenario.Respiratory medicine case reports · 2018Article
- Article
- Beyond Biomedicine: Relationships and Care in Tuberculosis Prevention.Journal of bioethical inquiry · 2016Article
- Calcified Pulmonary Nodules Identified in a 350-Year-Old-Joseon Mummy: the First Report on Ancient Pulmonary Tuberculosis from Archaeologically Obtained Pre-modern Korean Samples.Journal of Korean medical science · 2016Article
- Molecular studies on ancient M. tuberculosis and M. leprae: methods of pathogen and host DNA analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Review
- Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe.Nature communications · 2015Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seventy-one individuals from the late Neolithic population of the 7000-year-old site of Hódmezővásárhely-Gorzsa were examined for their skeletal palaeopathology. This revealed numerous cases of infections and non-specific stress indicators in juveniles and adults, metabolic diseases in juveniles, and evidence of trauma and mechanical changes in adults. Several cases showed potential signs of tuberculosis, particularly the remains of the individual HGO-53. This is an important finding that has significant implications for our understanding of this community. The aim of the present study was to seek biomolecular evidence to confirm this diagnosis. HGO-53 was a young male with a striking case of hypertrophic pulmonary osteopathy (HPO), revealing rib changes and cavitations in the vertebral bodies. The initial macroscopic diagnosis of HPO secondary to tuberculosis was confirmed by analysis of Mycobacterium tuberculosis complex specific cell wall lipid biomarkers and corroborated by ancient DNA (aDNA) analysis. This case is the earliest known classical case of HPO on an adult human skeleton and is one of the oldest palaeopathological and palaeomicrobiological tuberculosis cases to date.
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