ArticlePloS one2013
Longitudinal changes in the physical activity of adolescents with anorexia nervosa and their influence on body composition and leptin serum levels after recovery.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The effect of physical activity on health outcomes in individuals with anorexia nervosa: a systematic review and meta-analysis study.BMC psychiatry · 2026Pooled it
- Momentary physiological indices related to eating disorders: A systematic and methodological review.European eating disorders review : the journal of the Eating Disorders Association · 2024Pooled it
- Physical Activity in Eating Disorders: A Systematic Review.Nutrients · 2020Pooled it
- Pre-Treatment Fear of Weight Gain Is Associated With Engagement in a Greater Degree of Pre-Treatment Maladaptive Exercise Among Individuals With Binge-Spectrum Eating Disorders.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Brain, behavior, cognition, and physical health in first-onset adolescent anorexia nervosa: The BRAVE Study design and cohort profile.Aperture neuro · 2024Article
- Changes in unhealthy exercise in outpatient eating disorder treatment: examining emotion avoidance mechanisms.Eating and weight disorders : EWD · 2022Article
- High levels of physical activity in female adolescents with anorexia nervosa: medical and psychopathological correlates.Eating and weight disorders : EWD · 2022Article
- Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa.Biological psychiatry · 2021Article
- Physical activity and sleep during the first week of anorexia nervosa inpatient care.PloS one · 2021Observational
- Clinical, Psychopathological, Physical, and Sleep Evolution in Adolescents with Restrictive Anorexia Nervosa Participating in a Day Hospital Program.Psychiatry investigation · 2020Article
- Assessment of Physical Activity Patterns in Adolescent Patients with Anorexia Nervosa and Their Effect on Weight Gain.Journal of clinical medicine · 2020Article
- Moving beyond self-report data collection in the natural environment: A review of the past and future directions for ambulatory assessment in eating disorders.The International journal of eating disorders · 2019Review
- Autonomic Nervous System Response during Light Physical Activity in Adolescents with Anorexia Nervosa Measured by Wearable Devices.Sensors (Basel, Switzerland) · 2019Article
- Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin.Frontiers in psychology · 2019Review
- The Role of Objectively Measured, Altered Physical Activity Patterns for Body Mass Index Change during Inpatient Treatment in Female Patients with Anorexia Nervosa.Journal of clinical medicine · 2018Article
- Metabolic Barriers to Weight Gain in Patients With Anorexia Nervosa: A Young Adult Case Report.Frontiers in psychiatry · 2018Article
- Characterization and correlates of exercise among adolescents with anorexia nervosa and bulimia nervosa.The International journal of eating disorders · 2017Article
- Leptin and Physical Activity in Adult Patients with Anorexia Nervosa: Failure to Demonstrate a Simple Linear Association.Nutrients · 2017Observational
- Cannabinoid CBBritish journal of pharmacology · 2017Article
- Dimensions of Compulsive Exercise across Eating Disorder Diagnostic Subtypes and the Validation of the Spanish Version of the Compulsive Exercise Test.Frontiers in psychology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePatients with anorexia nervosa (AN) are often observed to have high levels of physical activity, which do not necessarily diminish after a successful therapy. Previous studies have shown that body fat tissue recovery in these patients is associated with a disproportional restoration of the adipocyte hormone, leptin. Therefore, we wondered whether the individual variation in physical activity in AN patients prior to treatment may be related to body fat percentage and plasma leptin level outcome.
methodBody fat percentage, leptin serum, and physical activity levels (accelerometer) were measured in adolescents with an (n=37, age 13 to 17.5 years) at initial assessment, at the end of study participation (median 12 months), and at one-year follow-up.
resultsAccelerometer data were used to split the patients in two groups: those with low (n=26) and those with high levels of physical activity (HLPA, n=11). These groups did not differ in terms of age, IQ, presence of menses, BMI and season of admission. The HLPA group was characterized by a longer total duration of illness. Physical activity levels during therapy decreased for the group with initially HLPA and increased for the group with low levels of physical activity (to comparable levels). Physical activity remained stable after one year. The increase in body fat percentage and leptin levels were dependent on the recovery status; however, recovered patients with initially HLPA had significantly higher fat mass during the follow-up. DISCUSSION: HLPA, an important modulator of AN progression in adolescents, can be successfully diminished by therapeutic intervention. Among recovered patients, those with initially HLPA had higher fat mass levels than those with low levels of physical activity. This finding suggests that HLPA are an important modulator of the body composition recovery mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.