ArticlePloS one2013
Mapping an atlas of tissue-specific Drosophila melanogaster metabolomes by high resolution mass spectrometry.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
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- Endosymbiont hijacking of acylcarnitines regulates insect vector fecundity by suppressing the viability of stored sperm.PLoS genetics · 2025Article
- Tissue-specific metabolomic signatures for aRoyal Society open science · 2025Article
- Biochemical Characteristics of Urine Metabolomics in Female Giant Pandas at Different Estrous Stages.Animals : an open access journal from MDPI · 2024Article
- Identification of high sugar diet-induced dysregulated metabolic pathways in muscle using tissue-specific metabolic models inbioRxiv : the preprint server for biology · 2024Article
- Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science.Current protocols · 2023Review
- Modular Evolution of the Drosophila Metabolome.Molecular biology and evolution · 2022Article
- Comparative metabolomic analysis of polyphenic horn development in the dung beetle Onthophagus taurus.PloS one · 2022Article
- Tissue-Specific Knockdown of Genes of the Argonaute Family Modulates Lifespan and Radioresistance in Drosophila Melanogaster.International journal of molecular sciences · 2021Article
- Intracellular Density ofmBio · 2021Article
- Beyond Sperm and Male Accessory Gland Proteins: Exploring Insect Reproductive Metabolomes.Frontiers in physiology · 2021Review
- Rapid local adaptation linked with phenotypic plasticity.Evolution letters · 2020Article
- Tissue-specific analysis of lipid species inJournal of lipid research · 2020Article
- Systems genetics of theGenome research · 2020Article
- Zika Virus Infection Results in Biochemical Changes Associated With RNA Editing, Inflammatory and Antiviral Responses inFrontiers in microbiology · 2020Article
- A Perspective and Framework for Developing Sample Type Specific Databases for LC/MS-Based Clinical Metabolomics.Metabolites · 2019Article
- Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster.Nature communications · 2019Article
- Article
- The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster.Scientific reports · 2018Article
- A prototypic small molecule database for bronchoalveolar lavage-based metabolomics.Scientific data · 2018Article
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5 authors.
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Abstract
Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues. Comprehensive metabolite profiles for ten tissues from adult Drosophila melanogaster were obtained here by two chromatographic methods, a hydrophilic interaction (HILIC) method for polar metabolites and a lipid profiling method also based on HILIC, in combination with an Orbitrap Exactive instrument. Two hundred and forty two polar metabolites were putatively identified in the various tissues, and 251 lipids were observed in positive ion mode and 61 in negative ion mode. Although many metabolites were detected in all tissues, every tissue showed characteristically abundant metabolites which could be rationalised against specific tissue functions. For example, the cuticle contained high levels of glutathione, reflecting a role in oxidative defence; the alimentary canal (like vertebrate gut) had high levels of acylcarnitines for fatty acid metabolism, and the head contained high levels of ether lipids. The male accessory gland uniquely contained decarboxylated S-adenosylmethionine. These data thus both provide valuable insights into tissue function, and a reference baseline, compatible with the FlyAtlas.org transcriptomic resource, for further metabolomic analysis of this important model organism, for example in the modelling of human inborn errors of metabolism, aging or metabolic imbalances such as diabetes.
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