ArticlePloS one2013
A multidisciplinary approach providing new insight into fruit flesh browning physiology in apple (Malus x domestica Borkh.).
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 94 citations in OpenAlex.
- Comparative enzymatic browning transcriptome analysis of three apple cultivars unravels a conserved regulatory network related to stress responses.BMC plant biology · 2025Article
- A Haplotype-resolved, Chromosome-scale Genome for Malus domestica Borkh. 'WA 38'.G3 (Bethesda, Md.) · 2024Article
- Genome-wide analysis of the polyphenol oxidase gene family reveals that MaPPO1 and MaPPO6 are the main contributors to fruit browning inFrontiers in plant science · 2023Article
- An Erwinia amylovora inducible promoter for improvement of apple fire blight resistance.Plant cell reports · 2022Article
- Apple (Plants (Basel, Switzerland) · 2021Article
- Determination of Post-Harvest Biochemical Composition, Enzymatic Activities, and Oxidative Browning in 14 Apple Cultivars.Foods (Basel, Switzerland) · 2021Article
- Multi-Omics Landscape of DNA Methylation Regulates Browning in "Fuji" Apple.Frontiers in nutrition · 2021Article
- Red to Brown: An Elevated Anthocyanic Response in Apple Drives Ethylene to Advance Maturity and Fruit Flesh Browning.Frontiers in plant science · 2019Article
- Deciphering the genetic control of fruit texture in apple by multiple family-based analysis and genome-wide association.Journal of experimental botany · 2017Article
- Polyphenol Oxidases in Crops: Biochemical, Physiological and Genetic Aspects.International journal of molecular sciences · 2017Article
- Biotechnology and apple breeding in Japan.Breeding science · 2016Review
- Genome investigation suggests MdSHN3, an APETALA2-domain transcription factor gene, to be a positive regulator of apple fruit cuticle formation and an inhibitor of russet development.Journal of experimental botany · 2015Article
- Location of chlorogenic acid biosynthesis pathway and polyphenol oxidase genes in a new interspecific anchored linkage map of eggplant.BMC plant biology · 2014Article
- Transcriptomic events associated with internal browning of apple during postharvest storage.BMC plant biology · 2014Article
- Genetic, metabolite and developmental determinism of fruit friction discolouration in pear.BMC plant biology · 2014Article
- Target metabolite and gene transcription profiling during the development of superficial scald in apple (Malus x domestica Borkh).BMC plant biology · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In terms of the quality of minimally processed fruit, flesh browning is fundamentally important in the development of an aesthetically unpleasant appearance, with consequent off-flavours. The development of browning depends on the enzymatic action of the polyphenol oxidase (PPO). In the 'Golden Delicious' apple genome ten PPO genes were initially identified and located on three main chromosomes (2, 5 and 10). Of these genes, one element in particular, here called Md-PPO, located on chromosome 10, was further investigated and genetically mapped in two apple progenies ('Fuji x Pink Lady' and 'Golden Delicious x Braeburn'). Both linkage maps, made up of 481 and 608 markers respectively, were then employed to find QTL regions associated with fruit flesh browning, allowing the detection of 25 QTLs related to several browning parameters. These were distributed over six linkage groups with LOD values spanning from 3.08 to 4.99 and showed a rate of phenotypic variance from 26.1 to 38.6%. Anchoring of these intervals to the apple genome led to the identification of several genes involved in polyphenol synthesis and cell wall metabolism. Finally, the expression profile of two specific candidate genes, up and downstream of the polyphenolic pathway, namely phenylalanine ammonia lyase (PAL) and polyphenol oxidase (PPO), provided insight into flesh browning physiology. Md-PPO was further analyzed and two haplotypes were characterised and associated with fruit flesh browning in apple.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.