ArticlePloS one2013
Transient receptor potential channels encode volatile chemicals sensed by rat trigeminal ganglion neurons.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Nanomolar vanillin, an e-cigarette flavorant, appears to disrupt pluripotency and promote endodermal differentiation in human embryonic stem cells via TRPV4 activation.Human reproduction (Oxford, England) · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Anesthetic- and Analgesic-Related Drugs Modulating Both Voltage-Gated NaBiomolecules · 2024Review
- Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors.Biomolecules & therapeutics · 2024Review
- Bitter Odorants and Odorous Bitters: Toxicity and Human TAS2R Targets.Journal of agricultural and food chemistry · 2023Article
- Testing effects of trigeminal stimulation on binary odor mixture quality in rats.Frontiers in neuroscience · 2023Article
- The effects of vanilloid analogues structurally related to capsaicin on the transient receptor potential vanilloid 1 channel.Biochemistry and biophysics reports · 2022Article
- Involvement of nasal trigeminal function in human stereo smelling.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- History repeats itself: Role of characterizing flavors on nicotine use and abuse.Neuropharmacology · 2020Review
- Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia.International journal of molecular sciences · 2020Review
- Effect of dibenz(b,f)-1,4-oxazepine aerosol on the breathing pattern and respiratory variables by continuous recording and analysis in unanaesthetised mice.Toxicology reports · 2020Article
- Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- To flourish or perish: evolutionary TRiPs into the sensory biology of plant-herbivore interactions.Pflugers Archiv : European journal of physiology · 2019Review
- The orotrigeminal system.Handbook of clinical neurology · 2019Review
- Ethyl Vanillin Activates TRPA1.The Journal of pharmacology and experimental therapeutics · 2017Article
- TRPM8 and Migraine.Headache · 2016Review
- Identification and functional characterization of TRPA1 in human myoblasts.Pflugers Archiv : European journal of physiology · 2016Article
- Enhanced nonpeptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch.The journal of pain · 2015Article
- RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors.PloS one · 2015Article
- Targeting TRP channels for novel migraine therapeutics.ACS chemical neuroscience · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary sensory afferents of the dorsal root and trigeminal ganglia constantly transmit sensory information depicting the individual's physical and chemical environment to higher brain regions. Beyond the typical trigeminal stimuli (e.g. irritants), environmental stimuli comprise a plethora of volatile chemicals with olfactory components (odorants). In spite of a complete loss of their sense of smell, anosmic patients may retain the ability to roughly discriminate between different volatile compounds. While the detailed mechanisms remain elusive, sensory structures belonging to the trigeminal system seem to be responsible for this phenomenon. In order to gain a better understanding of the mechanisms underlying the activation of the trigeminal system by volatile chemicals, we investigated odorant-induced membrane potential changes in cultured rat trigeminal neurons induced by the odorants vanillin, heliotropyl acetone, helional, and geraniol. We observed the dose-dependent depolarization of trigeminal neurons upon application of these substances occurring in a stimulus-specific manner and could show that distinct neuronal populations respond to different odorants. Using specific antagonists, we found evidence that TRPA1, TRPM8, and/or TRPV1 contribute to the activation. In order to further test this hypothesis, we used recombinantly expressed rat and human variants of these channels to investigate whether they are indeed activated by the odorants tested. We additionally found that the odorants dose-dependently inhibit two-pore potassium channels TASK1 and TASK3 heterologously expressed In Xenopus laevis oocytes. We suggest that the capability of various odorants to activate different TRP channels and to inhibit potassium channels causes neuronal depolarization and activation of distinct subpopulations of trigeminal sensory neurons, forming the basis for a specific representation of volatile chemicals in the trigeminal ganglia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.