ArticlePloS one2013
Chronic restraint stress upregulates erythropoiesis through glucocorticoid stimulation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Dihydrotanshinone I as a novel signal transducer and activator of transcription 3 inhibitor for glioblastoma treatment.Journal of translational medicine · 2026Article
- Blood Pharming of Red Cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026Review
- Resistance and Aerobic Preconditioning Delays Unloading-Induced Multisystemic Physiological Changes: The NEBULA Project.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Article
- Macrophages Provide Essential Support for Erythropoiesis, and Extracellular ATP Contributes to a Erythropoiesis-Supportive Microenvironment during Repeated Psychological Stress.International journal of molecular sciences · 2023Article
- Targeting Stress Erythropoiesis Pathways in Cancer.Frontiers in physiology · 2022Review
- Stress in paradise: effects of elevated corticosterone on immunity and avian malaria resilience in a Hawaiian passerine.The Journal of experimental biology · 2021Article
- Early life stress induces dysregulation of the heme pathway in adult mice.Physiological reports · 2021Article
- Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hematocrit, age, and survival in a wild vertebrate population.Ecology and evolution · 2021Article
- Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress.Histochemistry and cell biology · 2020Article
- Biomarker and hematological fieldwork with amphibians: is it necessary to sample all night?Environmental science and pollution research international · 2020Article
- Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production.Developmental cell · 2019Article
- Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading.Frontiers in physiology · 2019Article
- Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice.Scientific reports · 2018Article
- Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.Journal of neuroinflammation · 2017Article
- Article
- Macrophage migration inhibitory factor is an endogenous regulator of stress-induced extramedullary erythropoiesis.Histochemistry and cell biology · 2016Article
- Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice.Journal of radiation research · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In response to elevated glucocorticoid levels, erythroid progenitors rapidly expand to produce large numbers of young erythrocytes. Previous work demonstrates hematopoietic changes in rodents exposed to various physical and psychological stressors, however, the effects of chronic psychological stress on erythropoiesis has not be delineated. We employed laboratory, clinical and genomic analyses of a murine model of chronic restraint stress (RST) to examine the influence of psychological stress on erythropoiesis. Mice exposed to RST demonstrated markers of early erythroid expansion involving the glucocorticoid receptor. In addition, these RST-exposed mice had increased numbers of circulating reticulocytes and increased erythropoiesis in primary and secondary erythroid tissues. Mice also showed increases in erythroid progenitor populations and elevated expression of the erythroid transcription factor KLF1 in these cells. Together this work reports some of the first evidence of psychological stress affecting erythroid homeostasis through glucocorticoid stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.