ArticlePloS one2013
Enhancement of Cerenkov luminescence imaging by dual excitation of Er(3+),Yb(3+)-doped rare-earth microparticles.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 41 citations in OpenAlex.
- Radiopharmaceutical and EuJournal of nanobiotechnology · 2021Article
- Multiplex and In Vivo Optical Imaging of Discrete Luminescent Lanthanide Complexes Enabled by In Situ Cherenkov Radiation Mediated Energy Transfer.Journal of the American Chemical Society · 2021Article
- Radionuclide-Activated Nanomaterials and Their Biomedical Applications.Angewandte Chemie (International ed. in English) · 2019Review
- Multimodality Imaging Agents with PET as the Fundamental Pillar.Angewandte Chemie (International ed. in English) · 2019Review
- Enhanced Cerenkov luminescence tomography analysis based on YBiomedical optics express · 2018Article
- Cherenkov Radiation-Mediated In Situ Excitation of Discrete Luminescent Lanthanide Complexes.Angewandte Chemie (International ed. in English) · 2018Article
- Nanoparticles as multimodal photon transducers of ionizing radiation.Nature nanotechnology · 2018Article
- Practical Guidelines for Cerenkov Luminescence Imaging with Clinically Relevant Isotopes.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Molecular Imaging in Nanotechnology and Theranostics.Molecular imaging and biology · 2017Review
- Redshifted Cherenkov Radiation for in vivo Imaging: Coupling Cherenkov Radiation Energy Transfer to multiple Förster Resonance Energy Transfers.Scientific reports · 2017Article
- Utilizing the power of Cerenkov light with nanotechnology.Nature nanotechnology · 2017Review
- In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging.Nature communications · 2015Article
- Article
- Distance-dependent plasmon-enhanced fluorescence of upconversion nanoparticles using polyelectrolyte multilayers as tunable spacers.Scientific reports · 2015Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledCerenkov luminescence imaging (CLI) has been successfully utilized in various fields of preclinical studies; however, CLI is challenging due to its weak luminescent intensity and insufficient penetration capability. Here, we report the design and synthesis of a type of rare-earth microparticles (REMPs), which can be dually excited by Cerenkov luminescence (CL) resulting from the decay of radionuclides to enhance CLI in terms of intensity and penetration.
methodsYb(3+)- and Er(3+)- codoped hexagonal NaYF4 hollow microtubes were synthesized via a hydrothermal route. The phase, morphology, and emission spectrum were confirmed for these REMPs by power X-ray diffraction (XRD), scanning electron microscopy (SEM), and spectrophotometry, respectively. A commercial CCD camera equipped with a series of optical filters was employed to quantify the intensity and spectrum of CLI from radionuclides. The enhancement of penetration was investigated by imaging studies of nylon phantoms and nude mouse pseudotumor models.
resultsthe REMPs could be dually excited by CL at the wavelengths of 520 and 980 nm, and the emission peaks overlaid at 660 nm. This strategy approximately doubled the overall detectable intensity of CLI and extended its maximum penetration in nylon phantoms from 5 to 15 mm. The penetration study in living animals yielded similar results.
conclusionsthis study demonstrated that CL can dually excite REMPs and that the overlaid emissions in the range of 660 nm could significantly enhance the penetration and intensity of CL. The proposed enhanced CLI strategy may have promising applications in the future.
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