ArticlePloS one2013
Brown adipose tissue quantification in human neonates using water-fat separated MRI.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
- The interplay of Ashwagandha with hormonal dynamics and gut microbiota in women with breast cancer: a tri-axial perspective.Journal of natural medicines · 2026Review
- Cross-Generational Integration of Exercise and Nutritional Encoding in Offspring Adipose Genomics.International journal of molecular sciences · 2026Review
- Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders.Frontiers in pharmacology · 2025Article
- Infant body composition: A comprehensive overview of assessment techniques, nutrition factors, and health outcomes.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023Review
- Intraindividual difference between supraclavicular and subcutaneous proton density fat fraction is associated with cold-induced thermogenesis.Quantitative imaging in medicine and surgery · 2022Article
- Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Brown adipose tissue fat-fraction is associated with skeletal muscle adiposity.European journal of applied physiology · 2022Article
- The mysterious values of adipose tissue density and fat content in infants: MRI-measured body composition studies.Pediatric research · 2021Article
- Practical application of in vivo MRI-based brown adipose tissue measurements in infants.Obesity (Silver Spring, Md.) · 2021Article
- Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children.The Journal of clinical endocrinology and metabolism · 2021Article
- Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021Review
- Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent.Pflugers Archiv : European journal of physiology · 2020Article
- Investigation of the Relationship between MR-Based Supraclavicular Fat Fraction and Thyroid Hormones.Obesity facts · 2020Article
- Cold exposure induces dynamic, heterogeneous alterations in human brown adipose tissue lipid content.Scientific reports · 2019Article
- Differentiating supraclavicular from gluteal adipose tissue based on simultaneous PDFF and TJournal of magnetic resonance imaging : JMRI · 2019 · on this mapArticle
- Free-breathing 3-D quantification of infant body composition and hepatic fat using a stack-of-radial magnetic resonance imaging technique.Pediatric radiology · 2019Article
- MRI Assessment of Associations between Brown Adipose Tissue and Cachexia in Murine Pancreatic Ductal Adenocarcinoma.Internal medicine: open access · 2019Article
- Developmental patterns of fetal fat and corresponding signal on T1-weighted magnetic resonance imaging.Pediatric radiology · 2018Article
- Non-invasive methods for the assessment of brown adipose tissue in humans.The Journal of physiology · 2018Review
- Association of proton density fat fraction in adipose tissue with imaging-based and anthropometric obesity markers in adults.International journal of obesity (2005) · 2018Article
Corrections and comments
- Erratum issuedBurns, Joshua [added]
Authors and funding
12 authors at 2 institutions in 3 countries.
Funding
Abstract
There is a major resurgence of interest in brown adipose tissue (BAT) biology, particularly regarding its determinants and consequences in newborns and infants. Reliable methods for non-invasive BAT measurement in human infants have yet to be demonstrated. The current study first validates methods for quantitative BAT imaging of rodents post mortem followed by BAT excision and re-imaging of excised tissues. Identical methods are then employed in a cohort of in vivo infants to establish the reliability of these measures and provide normative statistics for BAT depot volume and fat fraction. Using multi-echo water-fat MRI, fat- and water-based images of rodents and neonates were acquired and ratios of fat to the combined signal from fat and water (fat signal fraction) were calculated. Neonatal scans (n = 22) were acquired during natural sleep to quantify BAT and WAT deposits for depot volume and fat fraction. Acquisition repeatability was assessed based on multiple scans from the same neonate. Intra- and inter-rater measures of reliability in regional BAT depot volume and fat fraction quantification were determined based on multiple segmentations by two raters. Rodent BAT was characterized as having significantly higher water content than WAT in both in situ as well as ex vivo imaging assessments. Human neonate deposits indicative of bilateral BAT in spinal, supraclavicular and axillary regions were observed. Pairwise, WAT fat fraction was significantly greater than BAT fat fraction throughout the sample (ΔWAT-BAT = 38 %, p<10(-4)). Repeated scans demonstrated a high voxelwise correlation for fat fraction (Rall = 0.99). BAT depot volume and fat fraction measurements showed high intra-rater (ICCBAT,VOL = 0.93, ICCBAT,FF = 0.93) and inter-rater reliability (ICCBAT,VOL = 0.86, ICCBAT,FF = 0.93). This study demonstrates the reliability of using multi-echo water-fat MRI in human neonates for quantification throughout the torso of BAT depot volume and fat fraction measurements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.