ArticlePloS one2013
Genetic variants in MUC4 gene are associated with lung cancer risk in a Chinese population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus inEpigenetics · 2022Article
- Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals.Environment international · 2022Article
- The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy.Cancer research · 2019Article
- miR-581-Related Single Nucleotide Polymorphism, rs2641726, Located in MUC4 Gene, is Associated with Gastric Cancer Incidence.Indian journal of clinical biochemistry : IJCB · 2019Article
- Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival.PloS one · 2019Article
- Two-stage study of lung cancer risk modification by a functional variant in the 3'-untranslated region ofMolecular and clinical oncology · 2018Article
- Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease.BioMed research international · 2017Article
- Identification of TRPCs genetic variants that modify risk for lung cancer based on the pathway and two-stage study.Meta gene · 2016Article
- Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases.Glycoconjugate journal · 2015Review
- [The reversing and molecular mechanisms of miR-503 on the drug-resistance to cisplatin in A549/DDP cells].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2014Article
- Prediction of disease genes using tissue-specified gene-gene network.BMC systems biology · 2014Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucin MUC4, which is encoded by the MUC4 gene, plays an important role in epithelial cell proliferation and differentiation. Aberrant MUC4 overexpression is associated with invasive tumor proliferation and poor outcome in epithelial cancers. Collectively, the existing evidence suggests that MUC4 has tumor-promoter functions. In this study, we performed a case-control study of 1,048 incident lung cancer cases and 1,048 age- and sex frequency-matched cancer-free controls in a Chinese population to investigate the role of MUC4 gene polymorphism in lung cancer etiology. We identified nine SNPs that were significantly associated with increased lung cancer risk (P = 0.0425 for rs863582, 0.0333 for rs842226, 0.0294 for rs842225, 0.0010 for rs2550236, 0.0149 for rs2688515, 0.0191 for rs 2641773, 0.0058 for rs3096337, 0.0077 for rs859769, and 0.0059 for rs842461 in an additive model). Consistent with these single-locus analysis results, the haplotype analyses revealed an adverse effect of the haplotype "GGC" of rs3096337, rs859769, and rs842461 on lung cancer. Both the haplotype and diplotype "CTGAGC" of rs863582, rs842226, rs2550236, rs842225, and rs2688515 had an adverse effect on lung cancer, which is also consistent with the single-locus analysis. Moreover, we observed statistically significant interactions for rs863582 and rs842461 in heavy smokers. Our results suggest that MUC4 gene polymorphisms and their interaction with smoking may contribute to lung cancer etiology.
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