ArticlePloS one2013
Correlated spontaneous activity persists in adult retina and is suppressed by inhibitory inputs.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Electrical Imaging of Light-Induced Signals Across and Within Retinal Layers.Frontiers in neuroscience · 2020Article
- Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells.Scientific reports · 2018Article
- Temporal properties of dual-peak responses of mouse retinal ganglion cells and effects of inhibitory pathways.Cognitive neurodynamics · 2016Article
- Aberrant Activity in Degenerated Retinas Revealed by Electrical Imaging.Frontiers in cellular neuroscience · 2016Review
- Elucidating the role of AII amacrine cells in glutamatergic retinal waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Differential alterations in the expression of neurotransmitter receptors in inner retina following loss of photoreceptors in rd1 mouse.PloS one · 2015Article
- Aberrant synaptic input to retinal ganglion cells varies with morphology in a mouse model of retinal degeneration.The Journal of comparative neurology · 2014Article
- Functional architecture of the retina: development and disease.Progress in retinal and eye research · 2014Review
- Slow feature analysis on retinal waves leads to V1 complex cells.PLoS computational biology · 2014Article
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Authors and funding
3 authors.
Funding
Abstract
Spontaneous rhythmic activity is a hallmark feature of the developing retina, where propagating retinal waves instruct axonal targeting and synapse formation. Retinal waves cease around the time of eye-opening; however, the fate of the underlying synaptic circuitry is unknown. Whether retinal waves are unique to the developing retina or if they can be induced in adulthood is not known. Combining patch-clamp techniques with calcium imaging, we demonstrate that propagative events persist in adult mouse retina when it is deprived of inhibitory input. This activity originates in bipolar cells, resembling glutamatergic stage III retinal waves. We find that, as it develops, the network interactions progressively curtail this activity. Together, this provides evidence that the correlated propagative neuronal activity can be induced in adult retina following the blockade of inhibitory interactions.
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Registered trials
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