ArticlePloS one2013
The syncytial Drosophila embryo as a mechanically excitable medium.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Manipulating the nature of embryonic mitotic waves.Current biology : CB · 2022Article
- Cullin-5 mutants reveal collective sensing of the nucleocytoplasmic ratio in Drosophila embryogenesis.Current biology : CB · 2022Article
- Waves in Embryonic Development.Annual review of biophysics · 2022Review
- Cellular Dialogues: Cell-Cell Communication through Diffusible Molecules Yields Dynamic Spatial Patterns.Cell systems · 2020Article
- Self-Similar Dynamics of Nuclear Packing in the Early Drosophila Embryo.Biophysical journal · 2019Article
- The Rise of Ultrafast Waves.Developmental cell · 2018Article
- Mechanical Model of Nuclei Ordering in Drosophila Embryos Reveals Dilution of Stochastic Forces.Biophysical journal · 2018Article
- Chemical waves in cell and developmental biology.The Journal of cell biology · 2018Review
- Mitotic waves in the early embryogenesis ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.Developmental cell · 2016Article
- Article
- Measuring time during early embryonic development.Seminars in cell & developmental biology · 2016Review
- Cell Surface Mechanochemistry and the Determinants of Bleb Formation, Healing, and Travel Velocity.Biophysical journal · 2016Article
- The mechanical properties of early Drosophila embryos measured by high-speed video microrheology.Biophysical journal · 2015Article
- Scaling laws governing stochastic growth and division of single bacterial cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Organization of early frog embryos by chemical waves emanating from centrosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Automated, contour-based tracking and analysis of cell behaviour over long time scales in environments of varying complexity and cell density.Journal of the Royal Society, Interface · 2014Article
- Spatiotemporal correlations between plastic events in the shear flow of athermal amorphous solids.The European physical journal. E, Soft matter · 2014Article
- A new way of tracking motion, shape, and divisions.European biophysics journal : EBJ · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitosis in the early syncytial Drosophila embryo is highly correlated in space and time, as manifested in mitotic wavefronts that propagate across the embryo. In this paper we investigate the idea that the embryo can be considered a mechanically-excitable medium, and that mitotic wavefronts can be understood as nonlinear wavefronts that propagate through this medium. We study the wavefronts via both image analysis of confocal microscopy videos and theoretical models. We find that the mitotic waves travel across the embryo at a well-defined speed that decreases with replication cycle. We find two markers of the wavefront in each cycle, corresponding to the onsets of metaphase and anaphase. Each of these onsets is followed by displacements of the nuclei that obey the same wavefront pattern. To understand the mitotic wavefronts theoretically we analyze wavefront propagation in excitable media. We study two classes of models, one with biochemical signaling and one with mechanical signaling. We find that the dependence of wavefront speed on cycle number is most naturally explained by mechanical signaling, and that the entire process suggests a scenario in which biochemical and mechanical signaling are coupled.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.